Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders

被引:215
作者
Barrera, Giuseppina [1 ]
Pizzimenti, Stefania [1 ]
Daga, Martina [1 ]
Dianzani, Chiara [2 ]
Arcaro, Alessia [3 ]
Cetrangolo, Giovanni Paolo [3 ]
Giordano, Giulio [4 ]
Cucci, Marie Angele [1 ]
Graf, Maria [4 ]
Gentile, Fabrizio [3 ]
机构
[1] Univ Torino, Dipartimento Sci Clin & Biol, I-10124 Turin, Italy
[2] Univ Torino, Dipartimento Sci & Tecnol Farm, I-10124 Turin, Italy
[3] Univ Molise, Dipartimento Med & Sci Salute V Tiberio, I-86100 Campobasso, Italy
[4] Azienda Sanit Reg Molise, Presidio Osped A Cardarelli, I-86100 Campobasso, Italy
关键词
aldehydes; osteopenia; sarcopenia; myelodysplastic syndromes; immunosenescence; OXIDATIVE STRESS; REACTIVE OXYGEN; HYDROGEN-PEROXIDE; LIFE EXPECTANCY; MUSCLE ATROPHY; CELLS; DIFFERENTIATION; SARCOPENIA; LEUKEMIA; GROWTH;
D O I
10.3390/antiox7080102
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Among the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and proteins, is by fueling the peroxidation of membrane lipids, leading to the production of several reactive aldehydes. Lipid peroxidation-derived aldehydes can not only modify biological macromolecules, by forming covalent electrophilic addition products with them, but also act as second messengers of oxidative stress, having relatively extended lifespans. Their effects might be further enhanced with aging, as their concentrations in cells and biological fluids increase with age. Since the involvement and the role of lipid peroxidation-derived aldehydes, particularly of 4-hydroxynonenal (HNE), in neurodegenerations, inflammation, and cancer, has been discussed in several excellent recent reviews, in the present one we focus on the involvement of reactive aldehydes in other age-related disorders: osteopenia, sarcopenia, immunosenescence and myelodysplastic syndromes. In these aging-related disorders, characterized by increases of oxidative stress, both HNE and malondialdehyde (MDA) play important pathogenic roles. These aldehydes, and HNE in particular, can form adducts with circulating or cellular proteins of critical functional importance, such as the proteins involved in apoptosis in muscle cells, thus leading to their functional decay and acceleration of their molecular turnover and functionality. We suggest that a major fraction of the toxic effects observed in age-related disorders could depend on the formation of aldehyde-protein adducts. New redox proteomic approaches, pinpointing the modifications of distinct cell proteins by the aldehydes generated in the course of oxidative stress, should be extended to these age-associated disorders, to pave the way to targeted therapeutic strategies, aiming to alleviate the burden of morbidity and mortality associated with these disturbances.
引用
收藏
页数:17
相关论文
共 101 条
[1]   Mitochondrial DNA deletion mutations and sarcopenia [J].
Aiken, J ;
Bua, E ;
Cao, ZJ ;
Lopez, M ;
Wanagat, J ;
McKenzie, D ;
McKiernan, S .
INCREASING HEALTHY LIFE SPAN: CONVENTIONAL MEASURES AND SLOWING THE INNATE AGING PROCESS, 2002, 959 :412-423
[2]  
Akpolat V, 2013, ADV CLIN EXP MED, V22, P403
[3]   Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids [J].
Almeida, Maria ;
Han, Li ;
Martin-Millan, Marta ;
Plotkin, Lilian I. ;
Stewart, Scott A. ;
Roberson, Paula K. ;
Kousteni, Stavroula ;
O'Brien, Charles A. ;
Bellido, Teresita ;
Parfitt, A. Michael ;
Weinstein, Robert S. ;
Jilka, Robert L. ;
Manolagas, Stavros C. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :27285-27297
[4]   Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66shc Signaling Cascade: Counter Regulation by Estrogens or Androgens [J].
Almeida, Maria ;
Han, Li ;
Ambrogini, Elena ;
Bartell, Shoshana M. ;
Manolagas, Stavros C. .
MOLECULAR ENDOCRINOLOGY, 2010, 24 (10) :2030-2037
[5]   Unraveling the mechanisms behind iron overload and ineffective hematopoiesis in myelodysplastic syndromes [J].
Angelucci, Emanuele ;
Cianciulli, Paolo ;
Finelli, Carlo ;
Mecucci, Cristina ;
Voso, Maria Teresa ;
Tura, Sante .
LEUKEMIA RESEARCH, 2017, 62 :108-115
[7]  
[Anonymous], OXIDATIVE MED CELL L
[8]   Role of 4-Hydroxynonenal-Protein Adducts in Human Diseases [J].
Barrera, Giuseppina ;
Pizzimenti, Stefania ;
Ciamporcero, Eric Stefano ;
Daga, Martina ;
Ullio, Chiara ;
Arcaro, Alessia ;
Cetrangolo, Giovanni Paolo ;
Ferretti, Carlo ;
Dianzani, Chiara ;
Lepore, Alessio ;
Gentile, Fabrizio .
ANTIOXIDANTS & REDOX SIGNALING, 2015, 22 (18) :1681-1702
[9]   Signaling pathways in skeletal muscle remodeling [J].
Bassel-Duby, Rhonda ;
Olson, Eric N. .
ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :19-37
[10]   Aging, inflammation and the environment [J].
Bektas, Arsun ;
Schurman, Shepherd H. ;
Sen, Ranjan ;
Ferrucci, Luigi .
EXPERIMENTAL GERONTOLOGY, 2018, 105 :10-18