An Efficient and Modular Route to Sequence- Defined Polymers Appended to DNA

被引：118

作者：

Edwardson, Thomas G. W. ^{[1
]}

Carneiro, Karina M. M. ^{[1
]}

Serpell, Christopher J. ^{[1
]}

Sleiman, Hanadi F. ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

amphiphiles; DNA; polymers; self-assembly; solid-phase synthesis; SYNTHETIC-POLYMERS; PEPTIDE-SYNTHESIS;

D O I：

10.1002/anie.201310937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inspired by biological polymers, sequence-controlled synthetic polymers are highly promising materials that integrate the robustness of synthetic systems with the information-derived activity of biological counterparts. Polymer-biopolymer conjugates are often targeted to achieve this union; however, their synthesis remains challenging. We report a stepwise solid-phase approach for the generation of completely monodisperse and sequence-defined DNA-polymer conjugates using readily available reagents. These polymeric modifications to DNA display self-assembly and encapsulation behavioras evidenced by HPLC, dynamic light scattering, and fluorescence studieswhich is highly dependent on sequence order. The method is general and has the potential to make DNA-polymer conjugates and sequence-defined polymers widely available.

引用

页码：4567 / 4571

页数：5

共 31 条

[1] Single Chain Folding of Synthetic Polymers by Covalent and Non-Covalent Interactions: Current Status and Future Perspectives
Altintas, Ozcan
Barner-Kowollik, Christopher
[J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2012, 33 (11) : 958 - 971
[2] DEOXYNUCLEOSIDE PHOSPHORAMIDITES - A NEW CLASS OF KEY INTERMEDIATES FOR DEOXYPOLYNUCLEOTIDE SYNTHESIS
BEAUCAGE, SL
CARUTHERS, MH
[J]. TETRAHEDRON LETTERS, 1981, 22 (20) : 1859 - 1862
[3] One-step formation of functionalized block copolymers
Benoit, D
Hawker, CJ
Huang, EE
Lin, ZQ
Russell, TP
[J]. MACROMOLECULES, 2000, 33 (05) : 1505 - 1507
[4] Stimuli-responsive organization of block copolymers on DNA nanotubes
Carneiro, Karina M. M.
Hamblin, Graham D.
Haenni, Kevin D.
Fakhoury, Johans
Nayak, Manoj K.
Rizis, Georgios
McLaughlin, Christopher K.
Bazzi, Hassan S.
Sleiman, Hanadi F.
[J]. CHEMICAL SCIENCE, 2012, 3 (06) : 1980 - 1986
[5] Lipid-anchored DNA mediates vesicle fusion as observed by lipid and content mixing
Chan, Yee-Hung M.
van Lengerich, Bettina
Boxer, Steven G.
[J]. BIOINTERPHASES, 2008, 3 (02) : FA17 - FA21
[6] Chien M.-P., 2010, ANGEW CHEM, V122, P5202
[7] Programmable Shape-Shifting Micelles
Chien, Miao-Ping
Rush, Anthony M.
Thompson, Matthew P.
Gianneschi, Nathan C.
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (30) : 5076 - 5080
[8] Edwardson TGW, 2013, NAT CHEM, V5, P868, DOI [10.1038/nchem.1745, 10.1038/NCHEM.1745]
[9] Rapid and quantitative one-pot synthesis of sequence-controlled polymers by radical polymerization
Gody, Guillaume
Maschmeyer, Thomas
Zetterlund, Per B.
Perrier, Sebastien
[J]. NATURE COMMUNICATIONS, 2013, 4
[10] GREENSPAN P, 1985, J LIPID RES, V26, P781

← 1 2 3 4 →