Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer

被引：36

作者：

Islam, Rajibul ^{[1
]}

Lam, Kok Wai ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Pharm, Drugs & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 207卷

关键词：

Triple-negative breast cancer; Small molecule agent; Targeted therapy; Immunotherapy; Combination therapy; HISTONE DEACETYLASE INHIBITOR; IN-VIVO ACTIVITY; TUMOR-GROWTH; ANTIPROLIFERATIVE ACTIVITY; PROTEASOME INHIBITOR; ANTITUMOR-ACTIVITY; DOWN-REGULATION; CDK INHIBITION; MUTANT P53; STEM-CELLS;

D O I：

10.1016/j.ejmech.2020.112812

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Triple-negative breast cancer (TNBC) is the most aggressive type of cancer, with a high risk of death on recurrence. To date, there is a lack of approved targeted agents for the treatment of the disease. Patients with TNBC continue to depend on surgery, chemotherapy, and radiotherapy, all of which have a wide side effect profile. In the present review, we highlight the current progress and exciting developments in the small-molecule targeted therapy for the treatment of TNBC. Finally, we also discuss the prospect of combining targeted therapy and immunotherapy for the effective treatment of TNBC. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

页数：21

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