The human short-chain dehydrogenase/reductase (SDR) superfamily: A bioinformatics summary

被引：86

作者：

Bray, James E. ^{[1
]}

Marsden, Brian D. ^{[1
]}

Oppermann, Udo ^{[1
]}

机构：

[1] Univ Oxford, Struct Genom Consortium, Oxford OX3 7DQ, England

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2009年 / 178卷 / 1-3期

基金：

英国惠康基金; 加拿大健康研究院;

关键词：

Short-chain dehydrogenase/reductase (SDR); Enzymes; Bioinformatics; Structure; Function; STRUCTURE PREDICTION; ENZYME; REDUCTASE; RETINOL; GENE; 17-BETA-HYDROXYSTEROID-DEHYDROGENASE; CLONING; SITE; ORIENTATION; EXPRESSION;

D O I：

10.1016/j.cbi.2008.10.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein super-families known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation. A simple scoring system for measuring structural and functional information (SIPS score) has also been introduced to monitor the status of 5 key metrics. Currently there are 17 SDR members with an SFS score of zero indicating that almost a quarter of the human SDR superfamily lacks substantial functional annotation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：99 / 109

页数：11

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