The human short-chain dehydrogenase/reductase (SDR) superfamily: A bioinformatics summary

被引:86
作者
Bray, James E. [1 ]
Marsden, Brian D. [1 ]
Oppermann, Udo [1 ]
机构
[1] Univ Oxford, Struct Genom Consortium, Oxford OX3 7DQ, England
基金
加拿大健康研究院; 英国惠康基金;
关键词
Short-chain dehydrogenase/reductase (SDR); Enzymes; Bioinformatics; Structure; Function; STRUCTURE PREDICTION; ENZYME; REDUCTASE; RETINOL; GENE; 17-BETA-HYDROXYSTEROID-DEHYDROGENASE; CLONING; SITE; ORIENTATION; EXPRESSION;
D O I
10.1016/j.cbi.2008.10.058
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein super-families known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation. A simple scoring system for measuring structural and functional information (SIPS score) has also been introduced to monitor the status of 5 key metrics. Currently there are 17 SDR members with an SFS score of zero indicating that almost a quarter of the human SDR superfamily lacks substantial functional annotation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:99 / 109
页数:11
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