Caveolae: Formation, dynamics, and function

被引：105

作者：

Parton, Robert G. ^{[1
,2
]}

Mcmahon, Kerrie-Ann ^{[1
]}

Wu, Yeping ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Ctr Microscopy & Microanal, Brisbane, Qld 4072, Australia

来源：

CURRENT OPINION IN CELL BIOLOGY | 2020年 / 65卷

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Caveolae; Caveolin; Cavin; Membrane traffic; Lipid; EHD2; PLASMA-MEMBRANE; STRUCTURAL INSIGHTS; SCAFFOLDING REGION; PROTEIN; FAMILY; CELLS; PHOSPHORYLATION; ORGANIZATION; METHYLATION; BIOGENESIS;

D O I：

10.1016/j.ceb.2020.02.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a platform generated by caveolin integral membrane proteins and membrane lipids. This membranous assembly can bud off into the cell or can be disassembled releasing the cavin proteins into the cytosol. Disassembly can be triggered by increased membrane tension, or by stress stimuli, such as UV. Here, we discuss recent mechanistic studies showing how caveolae are formed and how their unique properties allow them to function as multifunctional protective and signaling structures.

引用

页码：8 / 16

页数：9

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