Overlapping Structural and Functional Brain Changes in Patients With Long-Term Exposure to Fibromyalgia Pain

被引：170

作者：

Jensen, Karin B. ^{[1
,2
]}

Srinivasan, Priti ^{[1
,2
]}

Spaeth, Rosa ^{[1
,2
]}

Tan, Ying

Kosek, Eva ^{[4
]}

Petzke, Frank ^{[5
]}

Carville, Serena ^{[6
]}

Fransson, Peter ^{[4
]}

Marcus, Hanke ^{[7
]}

Williams, Steven C. R. ^{[8
]}

Choy, Ernest ^{[9
]}

Vitton, Olivier ^{[10
]}

Gracely, Richard ^{[11
]}

Ingvar, Martin ^{[4
]}

Kong, Jian ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[2] Athinoula A Martinos Ctr Biomed Imaging, Boston, MA USA

[3] Southwest Univ Nationalities, Chengdu, Peoples R China

[4] Karolinska Inst, Stockholm, Sweden

[5] Univ Gottingen, D-37073 Gottingen, Germany

[6] UK Age Res Forum, London, England

[7] Univ Hosp Cologne, Cologne, Germany

[8] Kings Coll London, London, England

[9] Cardiff Univ, Sch Med, Cardiff CF10 3AX, S Glam, Wales

[10] Pierre Fabre, Labege, France

[11] Univ N Carolina, Chapel Hill, NC USA

来源：

ARTHRITIS AND RHEUMATISM | 2013年 / 65卷 / 12期

关键词：

SURFACE-BASED ANALYSIS; REGIONAL HOMOGENEITY; WIDESPREAD PAIN; CLINICAL PAIN; CONNECTIVITY; SENSITIVITY; ABNORMALITIES; SEGMENTATION; RELIABILITY; PERCEPTION;

D O I：

10.1002/art.38170

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveThere is vast evidence to support the presence of brain aberrations in patients with fibromyalgia (FM), and it is possible that central plasticity is critical for the transition from acute to chronic pain. The aim of the present study was to investigate the relationship between brain structure and function in patients with FM. MethodsFunctional connectivity of the brain during application of intermittent pressure-pain stimuli and measures of brain structure were compared between 26 patients with FM and 13 age- and sex-matched healthy controls. Magnetic resonance imaging (MRI) was performed to obtain high-resolution anatomic images and functional MRI scans of the brain, which were used for measurements of pain-evoked brain activity. ResultsFM patients displayed a distinct overlap between decreased cortical thickness, decreased brain volumes, and decreased functional regional coherence in the rostral anterior cingulate cortex. The morphometric changes were more pronounced with longer exposure to FM pain. In addition, there was evidence of an association between structural and functional changes in the mesolimbic areas of the brain and the severity of comorbid depression symptoms in FM patients. ConclusionThe combined integration of structural and functional measures allowed for a unique characterization of the impact of FM pain on the brain. These data may lead to the identification of early structural and functional brain alterations in response to pain, which could be used to develop markers for predicting the development of FM and other pain disorders.

引用

页码：3293 / 3303

页数：11

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