Recent Progress on Synthesis of Fluorescein Probes

被引：55

作者：

Duan, Yousheng ^{[1
,2
]}

Liu, Ming ^{[2
]}

Sun, Wei ^{[2
]}

Wang, Min ^{[2
]}

Liu, Shangzhong ^{[2
]}

Li, Qing X. ^{[1
]}

机构：

[1] Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA

[2] China Agr Univ, Dept Appl Chem, Beijing 100094, Peoples R China

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 01期

关键词：

Fluorescein; fluorescent probe; fluorescent dye; fluorescence spectroscopy; GATED CHLORIDE CHANNEL; PHOTOBLEACHING KINETICS; INTRACELLULAR PH; MICROSCOPY; REAGENT; SERUM; FLUOROPHORES; DESIGN; ASSAY; OFMHA;

D O I：

10.2174/157019309787316111

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

After its first synthesis in 1871, fluorescein and its derivatives have been used as a powerful tool for molecular and cellular studies in biology, molecular biology, interactions between ligands and macromolecules, for drug discovery and environmental research. In recent 20 years, research attention has been paid particularly to synthesis and separation of fluorescein derivatives having various linker groups. This mini-review briefly summarizes synthesis of fluorescein derivatives for improving their chemical, fluorescent and biological properties and conjugation suitability.

引用

页码：35 / 43

页数：9

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