Recent Progress of DNAzyme-Nanomaterial Based Biosensors

被引：8

作者：

Zhao Xu-Hua ^{[1
]}

Meng Hong-Min ^{[2
]}

Gong Liang ^{[2
]}

Qiu Li-Ping ^{[2
]}

Zhang Xiao-Bing ^{[2
]}

Tan Wei-Hong ^{[2
]}

机构：

[1] Shanxi Med Univ, Dept Biochem & Mol Biol, Taiyuan 030001, Peoples R China

[2] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2015年 / 43卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DNAzymes; Nanomaterials; Biosensors; Review; ROLLING CIRCLE AMPLIFICATION; GRAPHENE OXIDE; QUANTUM DOTS; ELECTROCHEMICAL DETECTION; PB2+-DEPENDENT DNAZYME; GOLD NANOPARTICLES; CATALYTIC DNA; CLEAVING DNA; ENZYME-FREE; PB2+;

D O I：

10.1016/S1872-2040(15)60873-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

DNAzymes, screened through in vitro selection, were artificial nucleic acids with catalytic function. They could cleave specific substrates in the presence of cofactors with unique characteristics, such as high catalytic activity, high specificity for cofactors, excellent stability, and easy to synthesize and modify. The combination of DNAzymes with nanomaterials could retain the DNAzyme activity and realize the functional integration of recognition and signal transduction, promoting rapid development of biosensors. In the current paper, we have mainly reviewed the recent progress of DNAzyme-nanomaterial based biosensors, and the nanomaterials included gold nanoparticles, graphene, quantum dots, magnetic nanomaterials, and so on.

引用

页码：1611 / 1618

页数：8

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