Green Synthesis of Bis(indolyl)methanes Catalysed by Salicylic Acid

被引：0

作者：

Banari, Hoda ^{[1
]}

Kiyani, Hamzeh ^{[1
]}

Pourali, Alireza ^{[1
]}

机构：

[1] Damghan Univ, Sch Chem, Damghan 3671941167, Iran

来源：

CHIANG MAI JOURNAL OF SCIENCE | 2018年 / 45卷 / 01期

关键词：

3,3'-bis(indolyl)methanes; salicylic acid; indole; 2-methylindole; green; SOLVENT-FREE SYNTHESIS; EFFICIENT; MILD; TRIS(INDOLYL)METHANES; INDOLES; SYSTEM; WATER;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this contribution, salicylic acid (SA) has been used to catalyze synthesis of a series of biologically relevant 3,3'-bis(indolyl) methanes (BIMs) via the electrophilic substitution of indole derivatives on aldehyde compounds. The optimum catalyst loading was observed at 15 mol%. The procedure is simple and the expected bis-heterocyclic compounds were isolated in good to high yields. The present protocol provides the advantages of convenience, mild reaction conditions, eco-friendliness, energy-saving, and no use of hazardous solvents.

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页码：413 / 420

页数：8

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