B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failure

被引：9

作者：

Larsen, Alf Inge ^{[1
,2
]}

Skadberg, Oyvind ^{[3
]}

Aarsland, Torbjorn ^{[4
]}

Kvaloy, Jan Terje ^{[5
,6
]}

Lindal, Sigurd ^{[7
]}

Omland, Torbjorn ^{[8
]}

Dickstein, Kenneth ^{[1
,2
]}

机构：

[1] Stavanger Univ Hosp, Dept Cardiol, N-4001 Stavanger, Norway

[2] Univ Bergen, Inst Internal Med, Bergen, Norway

[3] Stavanger Univ Hosp, Div Biochem, N-4001 Stavanger, Norway

[4] Stavanger Hlth Res, Stavanger, Norway

[5] Univ Stavanger, Dept Math & Nat Sci, Stavanger, Norway

[6] Stavanger Univ Hosp, Div Res & Human Resources, N-4001 Stavanger, Norway

[7] Univ Tromso Hosp, Dept Pathol, Tromso, Norway

[8] Univ Oslo, Fac Div Akershus Univ Hosp, Oslo, Norway

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 136卷 / 03期

关键词：

Heart failure; BNP; ANP; Exercise; Skeletal muscle histology; Roundness; EXERCISE; MORPHOLOGY; ISCHEMIA; MEN;

D O I：

10.1016/j.ijcard.2008.04.085

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study examined the potential association between skeletal muscle histological findings and circulating levels of N-terminal Atrial natriuretic peptide (NT-proANP) and N-terminal B-type natriuretic peptide (NT-proBNP) at rest and during exercise in patients with moderate chronic heart failure. We report a significant correlation between muscle fibre roundness, defined as ratio of fibre perimeter squared to fibre area, and plasma levels of N-BNP. This finding suggests that the degree of intrafibrillar edema is related to the secretion of NT-proBNP. (C) 2008 Published by Elsevier Ireland Ltd.

引用

页码：358 / 362

页数：6

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