Innovation - High-throughput fluorescence microscopy for systems biology

被引：309

作者：

Pepperkok, Rainer ^{[1
]}

Ellenberg, Jan

机构：

[1] European Mol Biol Lab, Cell Biol Biophys Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany

[2] European Mol Biol Lab, Gene Express & Cell Biol Unit, D-69117 Heidelberg, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 09期

关键词：

PROTEIN-ANALYSIS; CELLS; MICROARRAYS; PROTEOMICS;

D O I：

10.1038/nrm1979

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this post-genomic era, we need to define gene function on a genome-wide scale for model organisms and humans. The fundamental unit of biological processes is the cell. Among the most powerful tools to assay such processes in the physiological context of intact living cells are fluorescence microscopy and related imaging techniques. To enable these techniques to be applied to functional genomics experiments, fluorescence microscopy is making the transition to a quantitative and high-throughput technology.

引用

页码：690 / 696

页数：7

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