MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research

被引：48
作者：
Andl, Thomas [1 ]
Botchkareva, Natalia V. [2 ]
机构：
[1] Vanderbilt Univ, Dept Med, Nashville, TN 37235 USA
[2] Univ Bradford, Fac Life Sci, Ctr Skin Sci, Bradford BD7 1DP, W Yorkshire, England
来源：
EXPERIMENTAL DERMATOLOGY | 2015年 / 24卷 / 11期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
development; hair cycle; hair follicle; microRNA; SKIN STEM-CELLS; TRANSCRIPTION FACTOR; FOLLICLE DEVELOPMENT; NONCODING RNA; MESSENGER-RNA; MELANOCYTE DEVELOPMENT; HEMATOPOIETIC STEM; SIGNALING CONTROLS; CODING REGIONS; GROWTH-FACTOR;
D O I：
10.1111/exd.12785
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Hair follicle development and its postnatal regeneration are characterized by dramatic changes in its microanatomy and cellular activity, which are controlled by multiple signalling pathways, transcription factors and epigenetic regulators, including microRNAs (miRNAs). miRNAs and their targets form remarkably diverse regulatory networks, playing a key role in the execution of gene expression programmes in the different cell lineages of the hair follicle. This review summarizes the roles of miRNAs in the control of hair follicle development, cycling and hair pigmentation, emphasizes the remaining problems/unanswered questions, and provides future directions in this rapidly growing and exciting area of research.
引用
收藏
页码：821 / 826
页数：6
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