N,N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

被引：23

作者：

Nie, Hong ^{[1
]}

Widdowson, Katherine L. ^{[1
]}

Palovich, Michael R. ^{[1
]}

Fu, Wei ^{[1
]}

Elliott, John D. ^{[1
]}

Bryan, Deborah L. ^{[1
]}

Burman, Miriam ^{[1
]}

Schmidt, Dulcie B. ^{[1
]}

Foley, James J. ^{[1
]}

Sarau, Henry M. ^{[1
]}

Busch-Petersen, Jakob ^{[1
]}

机构：

[1] GlaxoSmith Kline, King Of Prussia, PA 19406 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 21期

关键词：

CXCR2; CXCR1; cyanoguanidine;

D O I：

10.1016/j.bmcl.2006.08.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to > 200-fold. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5513 / 5516

页数：4

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