Association study of genetic markers of schizophrenia and its cognitive endophenotypes

被引：9
作者：
Bocharova, A. V. [1 ]
Stepanov, V. A. [1 ,2 ]
Marusin, A. V. [1 ]
Kharkov, V. N. [1 ,2 ]
Vagaitseva, K. V. [1 ,2 ]
Fedorenko, O. Yu. [3 ]
Bokhan, N. A. [2 ,3 ]
Semke, A. V. [3 ]
Ivanova, S. A. [3 ]
机构：
[1] Russian Acad Sci, Res Inst Med Genet, Tomsk 634050, Russia
[2] Natl Res Tomsk State Univ, Tomsk 634050, Russia
[3] Russian Acad Sci, Mental Hlth Res Inst, Tomsk 634014, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2017年 / 53卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
schizophrenia; cognitive endophenotypes; association study; multifactorial diseases; Russian population; GENOME-WIDE ASSOCIATION; RISK VARIANT RS10503253; CSMD1; POLYMORPHISM; PERFORMANCE; DISEASE; SYSTEM;
D O I：
10.1134/S1022795417010033
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A replicative analysis of associations of 15 SNPs located in the regions of 11 genes (TCF4, VRK2, NOTCH4, ZNF804A, AGBL1, RELN, ZFP64P1, KCNB2, CSMD1, CPVL, NRIP1) and three intergenic regions (SLCO6A1/LINCOO491, LOC105376248/LOC105376249, SPA17/NRGN) with schizophrenia was conducted in the Russian population of the Siberian region. These SNPs were previously identified in genome-wide association studies (GWAS) of schizophrenia and cognitive abnormalities. The present study confirmed associations of KCNB2 rs2247572, CSMD1 rs2616984, and intergenic rs12807809 located in SPA17/NRGN with schizophrenia. It was established that the frequency of the CSMD1 rs2616984 G/G genotype was higher in patients compared to the control group (OR = 1.73; CI: 1.14-2.62; NEuro = 0.0337). The frequencies of the KCNB2 rs2247572 TT genotype (OR = 0.41; CI: 0.20-0.87; NEuro = 0.0485) and intergenic rs12807809 CT genotype located in SPA17/NRGN (OR = 0.70; CI: 0.53-0.94; NEuro = 0.0464) were significantly decreased in patients compared to the control group.
引用
收藏
页码：139 / 146
页数：8
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