Direct monitoring of the asymmetric induction of solid-phase catalysis using circular dichroism:: Diamine-CuI-catalyzed asymmetric Henry reaction

The direct approach: A new high-throughput screening system for analyzing the asymmetric induction in catalytic enantioselective synthesis couples solid-phase reactions with a circular dichroism detection system (see picture). Thus, direct monitoring of asymmetric induction without the need for purification or chromatographic analysis is obtained. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.