Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: A new class of cytotoxic compounds

被引：9
作者：
Hadjipavlou, Christiana
Kostakisa, Ioannis K.
Pouli, Nicole
Marakos, Panagiotis
Pratsinis, Harris
Kletsas, Dimitris
机构：
[1] Univ Athens, Dept Pharm, Div Pharmaceut Chem, GR-15771 Athens, Greece
[2] NCSR Demokritos, Inst Biol, Lab Cell Proliferat & Ageing, Athens 15310, Greece
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 18期
关键词：
aminosubstituted benzopyrano[4,3,2-c,d]isoindoles; antiproliferative activity; DNA-content analysis;
D O I：
10.1016/j.bmcl.2006.06.074
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel aminosubstituted benzopyranoisoindoles possessing structural analogy to an active nitracrine metabolite are reported, The compounds exhibited interesting cytotoxic activity against a panel of cell lines, which was maximized by the presence of both 1-dialkylaminoethyl and 3-nitro substituents. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：4822 / 4825
页数：4
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