New phenolic principles from Hypericum sampsonii

被引：33

作者：

Don, MJ ^{[1
]}

Huang, YJ ^{[1
]}

Huang, RL ^{[1
]}

Lin, YL ^{[1
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 07期

关键词：

Hypericum sampsonii; benzophenone; xanthone; antraquinone; flavone;

D O I：

10.1248/cpb.52.866

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using the anti-hepatitis B virus (HBV)-producing cell line MS-G2 in vitro cultural system-guided screening was performed, and two new benzophenones, 2,6-dihydroxy-4-[(E)-5-hydroxy-3,7-dimethylocta-2,7-dienyl-oxy]benzophenone (1) and 2,6-dihydroxy-4-[(E)-7-hydroxy-3,7-dimethylocta-2-enyloxy]benzophenone (2), a new xanthone, hyperxanthone (3), a new bisanthraquinone glycoside, R-(-)-skyrin-6-O-beta-D-xylopyranoside (4), and 2-caffeoyloxy-3-hydroxy-3-(3,4-dihydroxyphenyl)propyl alcohol (5), and 16 known compounds were isolated from the anti-HBV active fraction of the whole herbs of Hypericum sampsonii. Their structures were elucidated using spectroscopic methods, mainly 2D NMR and MS spectrometry. Circular dichroism was used to determine the stereochemistry of bisanthraquinone glycosides.

引用

页码：866 / 869

页数：4

共 27 条

[1] XANTHONES AND VISMIONES FROM PSOROSPERMUM-FEBRIFUGUM [J].