Synthesis, Reactions, Characterization and Biological Evaluation of 2,3′-Bipyridine Derivatives (III)

1-Pyridin-3-yl-3-(2-thienyl of 2-furyl)prop-2-en-1-ones 1a, 1b reacted with 2-cyanoethanethioamide 2 to afford the corresponding 4-(thiophen-2-yl or furan-2-yl)-6-sulfanyl-2,3-bipyridine-5-carbonitriles 3a, 3b. The synthetic potentiality of compounds 3a, 3b were investigated in the present study via their reactions with several active halogen containing compounds 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 5, 5a, 5b. Our aim here is the synthesis of 4-(2-thienyl or 2-furyl)-6-pyridin-3-ylthieno[2,3-b]pyridin-3-amines 6a, 6b, 6c, 6d, 6e, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n,via 6-(alkyl-thio)-4-(2-thienyl or 2-furyl)-2,3-bipyridine-5-carbonitriles 5a, 5b, 5c, 5d, 5e, 5i, 5j, 5k, 5l, 5m. The structures of all newly synthesized heterocyclic compounds were elucidated by considering the data of IR, H-1-NMR, mass spectra, as well as that of elemental analyses. Anti-cancer, anti-Alzheimer, and anti-COX-2 activities were investigated for all the newly synthesized heterocyclic compounds.