Psychedelics and Neural Plasticity: Therapeutic Implications

被引:33
作者
Grieco, Steven F. [1 ]
Castren, Eero [2 ]
Knudsen, Gitte M. [3 ,4 ]
Kwan, Alex C. [5 ]
Olson, David E. [6 ,7 ,8 ]
Zuo, Yi [9 ]
Holmes, Todd C. [10 ,11 ]
Xu, Xiangmin [1 ,11 ]
机构
[1] Univ Calif Irvine, Dept Anat & Neurobiol, Sch Med, Irvine, CA 92697 USA
[2] Univ Helsinki, Neurosci Ctr HiLIFE, Helsinki 00014, Finland
[3] Univ Copenhagen, Neurobiol Res Unit, Copenhagen Univ Hosp, Rigshosp, DK-2200 Copenhagen, Denmark
[4] Univ Copenhagen, Dept Clin Med, DK-2200 Copenhagen, Denmark
[5] Cornell Univ, Meinig Sch Biomed Engn, Ithaca, NY 14853 USA
[6] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
[7] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Sacramento, CA 95817 USA
[8] Univ Calif Davis, Ctr Neurosci, Davis, CA 95618 USA
[9] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA
[10] Univ Calif Irvine, Dept Physiol & Biophys, Sch Med, Irvine, CA USA
[11] Univ Calif Irvine, Ctr Neural Circuit Mapping, Irvine, CA 92697 USA
基金
美国国家卫生研究院; 芬兰科学院;
关键词
psychedelics; psychoplastogens; plasticity; 5-HT2AR; circuits; OCULAR DOMINANCE PLASTICITY; LIFE-THREATENING CANCER; GENE C-FOS; PREFRONTAL CORTEX; ENVIRONMENTAL ENRICHMENT; FUNCTIONAL CONNECTIVITY; ANTIDEPRESSANT DRUGS; SYNAPTIC PLASTICITY; SEROTONIN RECEPTORS; NEUROTROPHIC FACTOR;
D O I
10.1523/JNEUROSCI.1121-22.2022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural attitudes toward them are changing, and scientists are once again investigating the neural mechanisms through which these drugs impact brain function. The signifi-cance of this research direction is reflected by recent work, including work presented by these authors at the 2022 meeting of the Society for Neuroscience. As of 2022, there were hundreds of clinical trials recruiting participants for testing the thera-peutic effects of psychedelics. Emerging evidence suggests that psychedelic drugs may exert some of their long-lasting thera-peutic effects by inducing structural and functional neural plasticity. Herein, basic and clinical research attempting to elucidate the mechanisms of these compounds is showcased. Topics covered include psychedelic receptor binding sites, effects of psychedelics on gene expression, and on dendrites, and psychedelic effects on microcircuitry and brain-wide circuits. We describe unmet clinical needs and the current state of translation to the clinic for psychedelics, as well as other unanswered basic neuroscience questions addressable with future studies.
引用
收藏
页码:8439 / 8449
页数:11
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