Application of bacteria and fungi as biocatalysts for the preparation of optically active hydroxyphosphonates

被引:79
作者
Kafarski, P [1 ]
Lejczak, B [1 ]
机构
[1] Wroclaw Univ Technol, Inst Organ Chem Biochem & Biotechnol, PL-50370 Wroclaw, Poland
关键词
whole-cell biocatalysis; biotransformations; enantioselectivity; chemo-enzymatic synthesis; organophosphorus compounds;
D O I
10.1016/j.molcatb.2003.12.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Review on the use of whole-cell biocatalysts for the preparation of optically active hydroxyalkanephosphonates is presented. There are three general processes applied so far, namely the use of lipolytic organisms either for enantio selective hydrolysis of acyloxyalkanephosphonates or enantioselective acylation of hydroxyalkanephosphonates, the use of baker's yeast and other fungi for bioreduction of ketophosphonates and the use of bacteria and fungi for hydrolytic oxirane ring opening in substituted 1,2-epoxyethanephosphonates. (C) 2004 Elsevier B.V. All rights reserved.
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页码:99 / 104
页数:6
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