Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling

被引：195
作者：
Lien, Wen-Hui [1 ,2 ]
Fuchs, Elaine [3 ]
机构：
[1] Duve Inst, B-1200 Brussels, Belgium
[2] Catholic Univ Louvain, B-1200 Brussels, Belgium
[3] Rockefeller Univ, Howard Hughes Med Inst, Lab Mammalian Cell Biol & Dev, New York, NY 10065 USA
来源：
GENES & DEVELOPMENT | 2014年 / 28卷 / 14期
基金：
美国国家卫生研究院;
关键词：
LEF/TCF; stem cells; Wnt signaling; beta-catenin; HAIR FOLLICLE MORPHOGENESIS; LABEL-RETAINING CELLS; VITAMIN-D-RECEPTOR; BETA-CATENIN; SELF-RENEWAL; IN-VIVO; SMALL-INTESTINE; FUNCTIONAL INTERACTION; REGULATORY CIRCUITRY; INTERACTION NETWORK;
D O I：
10.1101/gad.244772.114
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In mammals, Wnt/beta-catenin signaling features prominently in stem cells and cancers, but how and for what purposes have been matters of much debate. In this review, we summarize our current knowledge of Wnt/beta-catenin signaling and its downstream transcriptional regulators in normal and malignant stem cells. We centered this review largely on three types of stem cells-embryonic stem cells, hair follicle stem cells, and intestinal epithelial stem cells-in which the roles of Wnt/beta-catenin have been extensively studied. Using these models, we unravel how many controversial issues surrounding Wnt signaling have been resolved by dissecting the diversity of its downstream circuitry and effectors, often leading to opposite outcomes of Wnt/beta-catenin-mediated regulation and differences rooted in stage-and context-dependent effects.
引用
收藏
页码：1517 / 1532
页数：16
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