The first total synthesis of preverecynarmin

被引：1
作者：
Lan, J
Liu, ZS
Li, YL [1 ]
Cen, W
Xing, YC
机构：
[1] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Qingdao Univ, Dept Chem, Qingdao 266071, Peoples R China
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 1999年 / 46卷 / 06期
关键词：
total synthesis; macrocyclization; cemberenoid diterpene; regioselective epoxidation; preverecynarmin;
D O I：
10.1002/jccs.199900129
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Preverecynarmin, isolated from a pennatulacean coral, has been synthesized from E,E-farnesol. The key steps are alkylation of the cyanohydrin trimethylsilyl ether 5 with the halide 6, the regioselective epoxidation of the siloxyl ether 9, and the intramolecular macrocyclization of the siloxyl ether 12 induced by Ti(0).
引用
收藏
页码：941 / 946
页数：6
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