Role of Ionizing Radiation in Neurodegenerative Diseases

被引：49

作者：

Sharma, Neel K. ^{[1
]}

Sharma, Rupali ^{[2
]}

Mathur, Deepali ^{[3
]}

Sharad, Shashwat ^{[4
]}

Minhas, Gillipsie ^{[5
]}

Bhatia, Kulsajan ^{[6
]}

Anand, Akshay ^{[5
]}

Ghosh, Sanchita P. ^{[1
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Bethesda, MD 20814 USA

[2] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA

[3] KIIT Univ, Sch Biotechnol, Neurobiol Lab, Bhubaneswar, Odisha, India

[4] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA

[5] Postgrad Inst Med Educ & Res PGIMER, Dept Neurol, Neurosci Res Lab, Chandigarh, India

[6] Govt Med Coll & Hosp, Chandigarh, India

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2018年 / 10卷

关键词：

ionizing radiation; hypoxia; aging; neurodegenerative diseases; CNS; AMYOTROPHIC-LATERAL-SCLEROSIS; MITOCHONDRIAL-DNA DELETIONS; NEURAL PRECURSOR CELLS; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; ALPHA-SYNUCLEIN; COGNITIVE IMPAIRMENTS; MACULAR DEGENERATION;

D O I：

10.3389/fnagi.2018.00134

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Ionizing radiation (IR) from terrestrial sources is continually an unprotected peril to human beings. However, the medical radiation and global radiation background are main contributors to human exposure and causes of radiation sickness. At high-dose exposures acute radiation sickness occurs, whereas chronic effects may persist for a number of years. Radiation can increase many circulatory, age related and neurodegenerative diseases. Neurodegenerative diseases occur a long time after exposure to radiation, as demonstrated in atomic bomb survivors, and are still controversial. This review discuss the role of IR in neurodegenerative diseases and proposes an association between neurodegenerative diseases and exposure to IR.

引用

页数：15

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