Synthesis and promotion angiogenesis effect of chrysin derivatives coupled to NO donors

被引：16
作者：
Peng, Sheng-Ming [1 ]
Zou, Xiao-Qing [1 ]
Ding, Hua-Lan [1 ]
Ding, Yong-Lan [1 ]
Lin, Yuan-Bin [1 ]
机构：
[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environmentally Friendly Chem & Applicat, Xiangtan 411105, Hunan, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 04期
关键词：
Angiogenesis; Chrysin derivatives; Furazan derivatives; Alkyl nitrate; Couple; TEA POLYPHENOLS; ENDOTHELIAL-CELLS; FLAVONOIDS; RELEASE;
D O I：
10.1016/j.bmcl.2008.12.116
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two types of new chrysin derivatives were prepared by coupling NO donors of alkyl nitrate and furazan derivatives and were fully characterized by H-1 NMR and other techniques. These compounds were tested in human umbilical vein endothelial cells (HUVECs-12) and all the compounds exhibited cell proliferation. Notable effects of promoting angiogenesis were observed for all the modified compounds using chick chorioallantoic membrane (CAM) assay. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1264 / 1266
页数：3
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