Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells

被引：139

作者：

Burdon, T ^{[1
]}

Chambers, I ^{[1
]}

Stracey, C ^{[1
]}

Niwa, H ^{[1
]}

Smith, A ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Genome Res, Edinburgh EH9 3JQ, Midlothian, Scotland

来源：

CELLS TISSUES ORGANS | 1999年 / 165卷 / 3-4期

关键词：

embryonic stem cells; leukemia inhibitory factor; gp130; STAT3; extracellular regulated kinase;

D O I：

10.1159/000016693

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

An ability to propagate pluripotent embryonic cells in culture is the foundation both for defined germ line modification in experimental rodents and for future possibilities for broad-based cellular transplantation therapies in humans, Yet, the molecular basis of the self-renewing pluripotent phenotype remains ill-defined. The relationship between factors that influence embryonic stem cell propagation in vitro and mechanisms of stem cell regulation operative in the embryo is also uncertain, In this article we discuss the role of intracellular signalling pathways in the maintenance of pluripotency and induction of differentiation in embryonic stem cell cu Itu res a nd the mammalian embryo, Copyright (C) 1999 S. Karger AG. Basel.

引用

页码：131 / 143

页数：13

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