Autophagy: A novel therapeutic target for hepatocarcinoma

被引：34
作者：
Wang, Zhanggui [1 ]
Han, Weidong [1 ]
Sui, Xinbing [1 ]
Fang, Yong [1 ]
Pan, Hongming [1 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Hangzhou 310016, Zhejiang, Peoples R China
来源：
ONCOLOGY LETTERS | 2014年 / 7卷 / 05期
基金：
中国国家自然科学基金;
关键词：
autophagy; hepatocarcinoma; anti-hepatocarcinoma therapy; HEPATITIS-B-VIRUS; ISCHEMIA-REPERFUSION INJURY; BREAST-TUMOR CELLS; HEPATOCELLULAR-CARCINOMA; PHOTODYNAMIC THERAPY; MOLECULAR-MECHANISMS; CYTOTOXIC AUTOPHAGY; DUAL ROLE; PHASE-II; DEATH;
D O I：
10.3892/ol.2014.1916
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Autophagy is a highly conserved intracellular degradation process and plays an important role in hepatocarcinogenesis. Available data show that autophagy is involved in anti-hepatocarcinoma (HCC) therapies. Autophagy regulation involves a novel target for overcoming therapeutic resistance and sensitizing HCC to currently therapeutic methods. This is a systematic review on the interface of autophagy and the development of HCC and outlining the role of autophagy in current anti-HCC approaches. Understanding the significance of autophagy in anti-HCC therapy may offer a novel therapeutic target for improving anti-cancer efficacy and prolong survival for HCC patients.
引用
收藏
页码：1345 / 1351
页数：7
相关论文
共 84 条
[31]   p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia [J].
Hoshino, Atsushi ;
Matoba, Satoaki ;
Iwai-Kanai, Eri ;
Nakamura, Hideo ;
Kimata, Masaki ;
Nakaoka, Mikihiko ;
Katamura, Maki ;
Okawa, Yoshifumi ;
Ariyoshi, Makoto ;
Mita, Yuichiro ;
Ikeda, Koji ;
Ueyama, Tomomi ;
Okigaki, Mitsuhiko ;
Matsubara, Hiroaki .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (01) :175-184
[32]   Proteasome Inhibitor Interacts Synergistically With Autophagy Inhibitor to Suppress Proliferation and Induce Apoptosis in Hepatocellular Carcinoma [J].
Hui, Bo ;
Shi, Ying-Hong ;
Ding, Zhen-Bin ;
Zhou, Jian ;
Gu, Cheng-Yu ;
Peng, Yuan-Fei ;
Yang, Hua ;
Liu, Wei-Ren ;
Shi, Guo-Ming ;
Fan, Jia .
CANCER, 2012, 118 (22) :5560-5571
[33]   Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: Its role in tumor progression and apoptosis [J].
Huynh, H ;
Nguyen, TTT ;
Chow, KHP ;
Tan, PH ;
Soo, KC ;
Tran, E .
BMC GASTROENTEROLOGY, 2003, 3 (1)
[34]  
Kanzawa T, 2003, CANCER RES, V63, P2103
[35]   Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells [J].
Kim, Eun Hee ;
Sohn, Seonghyang ;
Kwon, Hyuk Jae ;
Kim, Seung U. ;
Kim, Min-Jung ;
Lee, Su-Jae ;
Choi, Kyeong Sook .
CANCER RESEARCH, 2007, 67 (13) :6314-6324
[36]   Involvement of mitophagy in oncogenic K-Ras-induced transformation Overcoming a cellular energy deficit from glucose deficiency [J].
Kim, June-Hyung ;
Kim, Hee Young ;
Lee, Young-Kyoung ;
Yoon, Young-Sil ;
Xu, Wei Guang ;
Yoon, Joon-Kee ;
Choi, Sung-E ;
Ko, Young-Gyu ;
Kim, Min-Jung ;
Lee, Su-Jae ;
Wang, Hee-Jung ;
Yoon, Gyesoon .
AUTOPHAGY, 2011, 7 (10) :1187-1198
[37]   Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma [J].
Kotsafti, Andromachi ;
Farinati, Fabio ;
Cardin, Romilda ;
Cillo, Umberto ;
Nitti, Donato ;
Bortolami, Marina .
BMC GASTROENTEROLOGY, 2012, 12
[38]   Autophagy and the Integrated Stress Response [J].
Kroemer, Guido ;
Marino, Guillermo ;
Levine, Beth .
MOLECULAR CELL, 2010, 40 (02) :280-293
[39]   Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures [J].
Lavanchy, D .
JOURNAL OF VIRAL HEPATITIS, 2004, 11 (02) :97-107
[40]   Hepatic ischemia reperfusion injury is associated with acute kidney injury following donation after brain death liver transplantation [J].
Leithead, Joanna A. ;
Armstrong, Matthew J. ;
Corbett, Christopher ;
Andrew, Mark ;
Kothari, Chirag ;
Gunson, Bridget K. ;
Muiesan, Paolo ;
Ferguson, James W. .
TRANSPLANT INTERNATIONAL, 2013, 26 (11) :1116-1125
123456789