Autophagy: A novel therapeutic target for hepatocarcinoma

被引：34

作者：

Wang, Zhanggui ^{[1
]}

Han, Weidong ^{[1
]}

Sui, Xinbing ^{[1
]}

Fang, Yong ^{[1
]}

Pan, Hongming ^{[1
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Hangzhou 310016, Zhejiang, Peoples R China

来源：

ONCOLOGY LETTERS | 2014年 / 7卷 / 05期

基金：

中国国家自然科学基金;

关键词：

autophagy; hepatocarcinoma; anti-hepatocarcinoma therapy; HEPATITIS-B-VIRUS; ISCHEMIA-REPERFUSION INJURY; BREAST-TUMOR CELLS; HEPATOCELLULAR-CARCINOMA; PHOTODYNAMIC THERAPY; MOLECULAR-MECHANISMS; CYTOTOXIC AUTOPHAGY; DUAL ROLE; PHASE-II; DEATH;

D O I：

10.3892/ol.2014.1916

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy is a highly conserved intracellular degradation process and plays an important role in hepatocarcinogenesis. Available data show that autophagy is involved in anti-hepatocarcinoma (HCC) therapies. Autophagy regulation involves a novel target for overcoming therapeutic resistance and sensitizing HCC to currently therapeutic methods. This is a systematic review on the interface of autophagy and the development of HCC and outlining the role of autophagy in current anti-HCC approaches. Understanding the significance of autophagy in anti-HCC therapy may offer a novel therapeutic target for improving anti-cancer efficacy and prolong survival for HCC patients.

引用

页码：1345 / 1351

页数：7

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