Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases

被引：92

作者：

Satoh, Minoru ^{[1
,2
]}

Vazquez-Del Mercado, Monica ^{[3
,4
,5
]}

Chan, Edward K. L. ^{[6
]}

机构：

[1] Univ Florida, Div Rheumatol & Clin Immunol, Dept Med, Gainesville, FL 32610 USA

[2] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA

[3] Inst Invest Reumatol & Sistema, Planta Baja 44240, Mexico

[4] Univ Guadalajara, Ctr Univ Ciencias Salud, Guadalajara, Jalisco, Mexico

[5] Hosp Civil Juan I, Div Med Interna, Dept Reumatol, Guadalajara, Jalisco, Mexico

[6] Univ Florida, Dept Oral Biol, Gainesville, FL 32610 USA

来源：

MODERN RHEUMATOLOGY | 2009年 / 19卷 / 03期

关键词：

Antinuclear antibodies; Autoantibodies; SLE; Scleroderma; Polymyositis; RNA-POLYMERASE-III; CONNECTIVE-TISSUE DISEASE; LINKED-IMMUNOSORBENT-ASSAY; LUPUS-ERYTHEMATOSUS; SJOGRENS-SYNDROME; AUTOIMMUNE-DISEASES; PULMONARY-FIBROSIS; SCLEROSIS; AUTOANTIBODIES; SERA;

D O I：

10.1007/s10165-009-0155-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoantibody tests have been used extensively in diagnosis and follow-up of patients in rheumatology clinics. Immunofluorescent antinuclear antibody test using HEp-2 cells is still considered the gold standard for screening of autoantibodies, and most of specific autoantibodies are currently tested by ELISA as a next step. Among the many autoantibody specificities described, some have been established as clinically useful diagnostic markers and are included in the classification criteria of diseases. Despite a long history of routine tests and attempts to standardize such assays, there are still limitations and problems that clinicians need to be aware of. Clinicians should be able to use autoantibody tests more efficiently and effectively with a basic knowledge on the significance of and potential problems in autoantibody tests.

引用

页码：219 / 228

页数：10

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