Potential cancer chemopreventive agents from Arbutus unedo

被引：36

作者：

Carcache-Blanco, Esperanza J.

Cuendet, Muriel

Park, Eun Jung

Su, Bao-Ning

Rivero-Cruz, J. Fausto

Farnsworth, Norman R.

Kinghorn, A. Douglas

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

来源：

NATURAL PRODUCT RESEARCH | 2006年 / 20卷 / 04期

关键词：

Arbutus unedo; sterols; pentacyclic triterpenes; 7; beta-hydroxystigmast-4-en-3-one; pomolic acid 3-acetate; JB6 cell transformation assay; cyclooxygenase-2 inhibition assay;

D O I：

10.1080/14786410500161205

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A phytochemical study of the petroleum ether and ethyl acetate extracts of the entire plant of Arbutus unedo led to the isolation of a new sterol, 7 beta-hydroxystigmast-4-en-3-one (1), and nine known compounds of the flavan, steroid, and terpenoid types. The structure of I was determined by spectroscopic data interpretation in combination with molecular modeling calculations. The absolute stereochemistry of C-7 was assigned as S for compound 1 based on the obtained CD spectral data. Activity in the JB6 cell transformation assay was found for pomolic acid 3-acetate (4). All isolates obtained were evaluated in a cyclooxygenase-2 (COX-2) inhibition assay.

引用

页码：327 / 334

页数：8