PD-L1-expressing extranodal diffuse large B-cell lymphoma, NOS with and without PD-L1 3′-UTR structural variations

被引：4

作者：

Takahara, Taishi ^{[1
]}

Ishikawa, Eri ^{[2
]}

Suzuki, Yuka ^{[3
]}

Kogure, Yasunori ^{[4
]}

Sato, Akira ^{[1
]}

Kataoka, Keisuke ^{[4
]}

Nakamura, Shigeo ^{[3
]}

机构：

[1] Aichi Med Univ Hosp, Dept Surg Pathol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Nagoya, Aichi, Japan

[3] Nagoya Univ Hosp, Dept Pathol & Lab Med, Nagoya, Aichi, Japan

[4] Natl Canc Ctr, Res Inst, Div Mol Oncol, Tokyo, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2022年 / 62卷 / 02期

关键词：

PD-L1; extranodal DLBCL; EXPRESSION; SURVIVAL;

D O I：

10.3960/jslrt.21028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune evasion mediated by PD-L1 plays an important role in the development of B-cell malignancies. However, PD-L1 expression is infrequently observed in tumor cells of extranodal diffuse large B-cell lymphoma. not otherwise specified (DLBCL, NOS). Other than copy number alterations. PD-L1 is aberrantly upregulated by structural variations in the 3'-UTR of PD-LI. We report four cases with PD-L1 expression on tumor cells, including two with structural variations in the 3'-UTR of PD-L1 and two without. Our report demonstrates the presence of a small number of "immune evasion-type" extranodal DLBCL, NOS cases.

引用

页码：106 / 113

页数：8

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