Hepatic arterial infusion chemoembolization therapy for advanced hepatocellular carcinoma: multicenter phase II study

被引:26
作者
Nagamatsu, Hiroaki [1 ]
Sumie, Shuji [2 ]
Niizeki, Takashi [2 ]
Tajiri, Nobuyoshi [2 ]
Iwamoto, Hideki [2 ]
Aino, Hajime [2 ]
Nakano, Masahito [2 ]
Shimose, Shigeo [2 ]
Satani, Manabu [2 ]
Okamura, Shusuke [2 ]
Kuromatsu, Ryoko [2 ]
Matsugaki, Satoshi [3 ]
Kurogi, Junichi [4 ]
Kajiwara, Masahiko [4 ]
Koga, Hironori [2 ]
Torimura, Takuji [2 ]
机构
[1] Yame Republ Hosp, Dept Gastroenterol, Yame, Japan
[2] Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan
[3] Tobata Republ Hosp, Dept Gastroenterol, Kitakyushu, Fukuoka, Japan
[4] Asakura Med Assoc Hosp, Dept Gastroenterol, Asakura City, Japan
基金
日本学术振兴会;
关键词
Hepatocellular carcinoma; Hepatic arterial infusion chemotherapy; Portal vein tumor thrombosis; Cisplatin; 5-Fluorouracil; VEIN TUMOR THROMBOSIS; SUBCUTANEOUS INTERFERON-ALPHA; PORTAL-VEIN; INTRAARTERIAL; 5-FLUOROURACIL; PROGNOSTIC-FACTORS; LIVER RESECTION; SURVIVAL; CHEMOTHERAPY; SORAFENIB; CISPLATIN;
D O I
10.1007/s00280-015-2892-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Portal vein tumor thrombosis is a critical complication in patients with hepatocellular carcinoma (HCC). This prospective multicenter trial assessed the efficacy of hepatic arterial infusion chemoembolization therapy with cisplatin suspended in lipiodol combined with 5-fluorouracil for HCC patients with portal vein tumor thrombosis. We enrolled 52 HCC patients with portal vein tumor thrombosis. They received hepatic arterial infusion chemoembolization therapy with cisplatin suspension in lipiodol and 5-fluorouracil. The primary efficacy endpoint was progression-free survival (PFS), while the secondary endpoints were overall survival (OS), tumor response rate, safety, and tolerability. Independent factors for survival were also evaluated. The median PFS and OS were 8.6 and 27.0 months, respectively. Ten patients showed complete response, while 29 had partial response (response rate, 75.0 %). The median survival time of 10 patients with complete response and 29 with partial response was 32 months, while that of 15 patients with partial response who later showed disappearance of HCC following additional therapies was 50 months. Multivariate analysis identified response to treatment and disappearance of viable HCC as independent predictors of survival. The treatment was well tolerated, and the only encountered Grade 3 toxicities were thrombocytopenia and hyperbilirubinemia. Hepatic arterial infusion chemoembolization therapy with cisplatin suspension in lipiodol combined with 5-fluorouracil is effective treatment for unresectable HCC with portal vein tumor thrombosis.
引用
收藏
页码:243 / 250
页数:8
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