The relationships between 7-kchol, 7β-ohchol, chol-triol, Lp (A) and PON1 with coronary heart disease in patients with diabetes mellitus T1DM and T2DM

被引：1

作者：

Ahmed, Ahmed Mohammed ^{[1
]}

Khabour, Omar F. ^{[2
]}

Yousuf, Amjad ^{[1
]}

Mohammedsaeed, Walaa ^{[1
]}

Alahmadi, Nawaf Fawaz ^{[1
]}

Alshangeety, Ahmad Mahmood ^{[1
]}

Alotaibi, Omar Howadi ^{[1
]}

Alhaidary, Amer Abdullah ^{[1
]}

机构：

[1] Taibah Univ, Fac Appl Med Sci, Dept Med Lab Technol, Madinah, Saudi Arabia

[2] Jordan Univ Sci & Technol, Dept Med Lab Sci, Irbid, Jordan

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2022年 / 35卷 / 03期

关键词：

Oxysterols; 7-ketocholesterol; 7; beta-hydroxycholesterol; triol; Type 1 diabetes mellitus; type 2 diabetes mellitus; OXIDATIVE STRESS; OXYSTEROLS; 7-KETOCHOLESTEROL; LIPOPROTEIN; CHOLESTEROL; PATHWAYS; ASPIRIN; PLASMA;

D O I：

10.36721/PJPS.2022.35.3.REG.761-768.1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxysterols (OXY) are oxidized derivatives of cholesterol associated with oxidation and can increase the risk of cardiovascular diseases. The aim of the current study is to examine the relationships between OXY profile, lipids, lipoprotein(a) [Lp(a)] and paraoxonasel (PON1) with coronary heart disease (CHD) in patients with diabetes mellitus typel (T1DM) and type2 (T2DM). 120 diabetic patients (T1DM=40, T2DM=80) and 60 healthy subjects were recruited in the study. OXY profile (7-KChol, 7 beta-OHChol and Chol-triol) was measured using liquid chromatography-mass spectrometry. The clinical profile of the study participants was also collected. 7-KChol, 7 beta-OHChol and Chol-triol and Lp(a), FBG and glycation parameters were higher in diabetic patients compared to controls (p<0.01), whereas PON1 was lower in patients compared to controls (p<0.01). Within the T2DM group, 7-KChol and 7 beta-OHChol levels were associated with CHD, obesity, and smoking (p<0.05). In addition, KChol, 7 beta-OHChol and Chol-triol levels were associated with smoking in T1DM (p<0.05). In both diabetic types, 7-KChol, 7 beta-OHChol and Chol-triol were significantly correlated with TC, LDL, ApoB and Lp(a), glycation parameters and inversely with PON1 (p<0.05). OXY profile in diabetic patients can be used as a reliable biomarker of CHD, particularly in T2DM.

引用

页码：761 / 768

页数：8