STAT6 inhibits T-bet-independent Th1 cell differentiation

被引：12
|
作者：
Tamachi, Tomohiro [2 ]
Takatori, Hiroaki [2 ]
Fujiwara, Michio [2 ]
Hirose, Koichi [2 ]
Maezawa, Yuko [2 ]
Kagami, Shin-ichiro [1 ,2 ]
Suto, Akira [1 ,2 ]
Watanabe, Norihiko [2 ]
Iwamoto, Itsuo [3 ]
Nakajima, Hiroshi [1 ,2 ]
机构：
[1] Chiba Univ, Grad Sch Med, Dept Mol Genet, Chiba 2608670, Japan
[2] Chiba Univ, Dept Allergy & Clin Immunol, Chiba 2608670, Japan
[3] Asahi Gen Hosp, Res Ctr Allergy & Clin Immunol, Chiba, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 382卷 / 04期
关键词：
Th1/Th2; Cells; T-bet; STAT6; STAT4; IFN-GAMMA PRODUCTION; TRANSCRIPTION; EXPRESSION; RESPONSES; EOMESODERMIN; COMMITMENT; CD4;
D O I：
10.1016/j.bbrc.2009.03.101
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
STAT6 plays critical roles in Th2 cell differentiation, whereas STAT4 and T-bet are important for Th1 cell differentiation. However, it is still largely unknown about the cross talk of these transcription factors during Th1/Th2 cell differentiation. To further address the regulatory mechanisms underlying Th1/Th2 cell differentiation, we generated the mice lacking both STAT6 and T-bet (STAT(-/-) T-bet(-/-) mice). Importantly, although Th2 cell differentiation was severely and similarly decreased in STAT6(-/-) T-bet(-/-) mice and STAT6(-/-) mice. Th1 cell differentiation was rescued in part in STAT6(-/-) T-bet(-/-) mice as compared with that in T-bet(-/-). While no significant difference was observed in the expression of IL-12R beta 2 and STAT4 between STAT6(-/-) T-bet(-/-) CD4(+) T cells and T-bet(-/-) CD4(+) T cells, IL-12-induced STAT4 phosphorylation was increased in STAT6(-/-) T-bet(-/-) CD4(+) T cells as compared with that in T-bet(-/-) CD4(+) T cells. These results indicate that STAT6 inhibits T-bet-independent Th1 cell differentiation by suppressing IL-12-STAT4 signaling. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：751 / 755
页数：5
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