Subcutaneous immunoglobulin in CIDP and MMN: a short-term nationwide study

被引：60

作者：

Cocito, Dario ^{[1
]}

Merola, Aristide ^{[1
]}

Peci, Erdita ^{[1
]}

Mazzeo, Anna ^{[2
]}

Fazio, Raffaella ^{[3
]}

Francia, Ada ^{[4
]}

Valentino, Paola ^{[5
]}

Liguori, Rocco ^{[6
]}

Filosto, Massimiliano ^{[7
,8
]}

Siciliano, Gabriele ^{[9
]}

Clerici, Angelo Maurizio ^{[10
]}

Lelli, Stefania ^{[11
]}

Marfia, Girolama Alessandra ^{[12
]}

Antonini, Giovanni ^{[13
]}

Cecconi, Ilaria ^{[14
]}

Nobile-Orazio, Eduardo ^{[15
]}

Lopiano, Leonardo ^{[1
]}

机构：

[1] Univ Turin, Dept Neurosci, I-10126 Turin, Italy

[2] AOU Policlin G Martino, Dept Neurosci Psychiat & Anesthesiol, Messina, Italy

[3] IRCCS San Raffaele Milano, Dept Neurol, Milan, Italy

[4] Policlin Umberto 1, Neurol Clin 3, Rome, Italy

[5] Univ Magna Grecia Catanzaro, Dept Med & Surg Sci, Neurol Clin, Catanzaro, Italy

[6] IRCCS, Inst Neurol Sci Bologna, Neurol Clin, Bologna, Italy

[7] Univ Brescia, Neurol Clin, Neuromuscular Dis & Neuropathies Sect, Brescia, Italy

[8] AO Spedali Civili Brescia, Brescia, Italy

[9] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[10] Univ Insubria, AO Hosp Varese Circolo & Fdn Macchi, Neurol & Stroke Unit, Varese, Italy

[11] Hosp San Giacomo Apostolo, Neurol Unit, Castelfranco Veneto, Italy

[12] Policlin Tor Vergata, Dept Neurosci, Rome, Italy

[13] Univ Roma La Sapienza, I-00185 Rome, Italy

[14] Hosp St Orsola Malpighi Bologna, Child Neuropsychiat Unit, Bologna, Italy

[15] Univ Milan, IRCCS Ist Clin Humanitas, Dept Translat Med, Rozzano, Italy

来源：

JOURNAL OF NEUROLOGY | 2014年 / 261卷 / 11期

关键词：

Chronic inflammatory demyelinating polyneuropathy; Multifocal motor neuropathy; Subcutaneous immunoglobulin; Intravenous immunoglobulin; Inflammatory neuropathy; MULTIFOCAL MOTOR NEUROPATHY; INFLAMMATORY DEMYELINATING POLYNEUROPATHY; PERIPHERAL-NERVE SOCIETY; JOINT TASK-FORCE; SERUM IGG LEVELS; QUALITY-OF-LIFE; INTRAVENOUS IMMUNOGLOBULIN; NEUROLOGICAL SOCIETIES; EUROPEAN FEDERATION; SELF-INFUSIONS;

D O I：

10.1007/s00415-014-7444-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This multi-center Italian prospective observational study reports the 4 months follow-up data of 87 patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) shifted from intravenous to subcutaneous immunoglobulin treatment. A therapeutic shift from intravenous to subcutaneous immunoglobulin was performed in 87 patients (66 CIDP; 21 MMN) affected by immune-mediated peripheral neuropathies with evidence of a sustained clinical response to intravenous immunoglobulin. Patients were evaluated by means of the Overall Neuropathy Limitation Scale, Medical Research Council Scale and Life Quality Index questionnaire, both at the time of therapeutic shift and after 4 months of subcutaneous immunoglobulin treatment. A sustained clinical efficacy was observed after the switch to subcutaneous immunoglobulin: the Overall Neuropathy Limitation Scale score improved in the group of 66 CIDP patients (P = 0.018), with only one subject reporting a worsening of 1 point, and remained stable in the group of 21 MMN patients (P = 0.841), with one subject reporting a worsening of two points. An improvement in the patient's perception of therapeutic setting was reported in both groups. This large multi-center study confirms the short-term clinical equivalence of subcutaneous versus intravenous immunoglobulin and a possible improvement in the patient's perception of therapeutic setting with the subcutaneous administration. However, further studies are required to extend the results to a longer observational period.

引用

页码：2159 / 2164

页数：6

共 20 条

[1] Nerve excitability changes after intravenous immunoglobulin infusions in multifocal motor neuropathy and chronic inflammatory demyelinating neuropathy [J].