Balamuthia mandrillaris meningoencephalitis in an immunocompromised patient Case report

被引:5
作者
Kansagra, Akash P. [1 ]
Menon, Jayant P. [2 ]
Yarbrough, Chester K. [1 ]
Urbaniak, Klaudia [2 ]
Waters, J. Dawn [2 ]
Borys, Ewa [3 ]
Jandial, Rahul [2 ,4 ]
机构
[1] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Neurosurg, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
[4] Burnham Inst Med Res, Ctr Neurosci Aging & Stem Cell Res, La Jolla, CA USA
关键词
ameba; Balamuthia mandrillaris; encephalitis; immune deficiency; GRANULOMATOUS AMEBIC ENCEPHALITIS; RIBOSOMAL-RNA GENE; OPPORTUNISTIC AMEBAS; PCR ASSAY; IDENTIFICATION; ANIMALS; HUMANS; AGENT; SERUM;
D O I
10.3171/2008.9.JNS08718
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Balamuthia mandrillaris is a rare but increasingly recognized cause of amebic encephalitis, yet it remains poorly understood. The condition is almost universally fatal, and due to diagnostic difficulty, most cases are identified postmortem. The authors report a case of Balamuthia amebic encephalitis in a patient with combined variable immunodeficiency in which a rare antemortem diagnosis was made via brain biopsy. Despite broad-spectrum antimicrobial therapy, the Outcome was fatal. Such presentations are challenging, and definitive diagnosis may require biopsy in consultation with a skilled neuropathologist. (DOI: 10.3171/2008.9.JNS08718)
引用
收藏
页码:301 / 305
页数:5
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