Triterpenoids with antimicrobial activity from Drypetes inaequalis

被引：40

作者：

Awanchiri, Simon Suh ^{[1
]}

Trinh-Van-Dufat, Hanh ^{[3
]}

Shirri, Jovita Chi ^{[1
]}

Dongfack, Marlise Diane J. ^{[1
]}

Nguenang, Guy Merlin ^{[2
]}

Boutefnouchet, Sabrina ^{[3
]}

Fomum, Zacharias T. ^{[1
]}

Seguin, Elisabeth ^{[5
]}

Verite, Philippe ^{[4
]}

Tillequin, Francois ^{[3
]}

Wandji, Jean ^{[1
]}

机构：

[1] Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon

[2] Univ Yaounde I, Dept Vegetal Biol & Physiol, Fac Sci, Yaounde, Cameroon

[3] Univ Paris 05, Lab Pharmacognosie, Fac Sci Biol & Pharmaceut, CNRS,UMR 8638, F-75006 Paris, France

[4] UFR Med Pharm Rouen, Chim Analyt Lab, F-76183 Rouen 1, France

[5] UFR Med Pharm Rouen, Lab Pharmacognosie, F-76183 Rouen 1, France

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 03期

关键词：

Drypetes inaequalis; Euphorbiaceae; Stems; Fruit; Triterpenoid esters; Saponins; Antimicrobial activity; SAPONINS;

D O I：

10.1016/j.phytochem.2008.12.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The air-dried stems and ripe fruit of Drypetes inaequalis Hutch. (Euphorbiaceae) were studied. Four triterpene derivatives, characterized as lup-20(29)-en-3 beta,6 alpha-diol, 3 beta-acetoxylup-20(29)-en-6 alpha-ol. 3 beta-caffeoyloxylup-20(29)-en-6 alpha-ol and 28-beta D-glucopyranosyl-30-methyl 3 beta-hydroxyolean-12-en-28,30-dioate along with 10 known compounds were isolated from the whole stems. One triterpene. characterized as 3 alpha-hydroxyfriedelan-25-al along with six known compounds were isolated from the ripe fruit. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The triterpenes were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and two of them appeared to be modestly active. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：419 / 423

页数：5

共 21 条

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