Levodopa effect on spontaneous speech in Parkinson's disease

被引:1
作者
Bayram, Ece [1 ]
Aslanbaba, Eda [2 ]
Akbostanci, Muhittin Cenk [1 ,2 ]
机构
[1] Ankara Univ, Dept Interdisciplinary Neurosci, Ibni Sina Hastanesi, Talatpasa Bulv 82, TR-06230 Ankara, Turkey
[2] Ankara Univ, Dept Neurol, Ibni Sina Hastanesi, Talatpasa Bulv 82, TR-06230 Ankara, Turkey
关键词
Levodopa; Word production; Verb; Noun; Parkinson's disease; MONTREAL COGNITIVE ASSESSMENT; NONDEMENTED PATIENTS; DIAGNOSTIC-CRITERIA; VERB GENERATION; TASK; STIMULATION; FLUENCY; MOTOR; MOCA;
D O I
10.1016/j.jneuroling.2019.03.001
中图分类号
H0 [语言学];
学科分类号
030303 ; 0501 ; 050102 ;
摘要
Parkinson's disease (PD) is associated with verb deficits detected with tasks including picture naming and verbal fluency. However, these deficits are not frequently reported by the patients themselves. Levodopa, the gold standard for motor symptoms in PD, has been previously implicated to improve these verb deficits. We evaluated the effect of levodopa by using a spontaneous speech task which is more naturalistic than the previously used tasks to detect verb deficits. Thirty PD patients, and 30 age-, gender-, years of education-matched healthy controls were included. Patients were tested while motor 'on' and 'off. Levodopa did not affect spontaneous speech, although it improved the motor symptoms. Compared to controls, PD patients produced shorter and a lower number of sentences. The verb deficit was independent of cognitive or motor performance. The pathophysiology of motor symptoms and verb deficits most likely differ, and levodopa does not improve verb deficits during spontaneous speech.
引用
收藏
页码:194 / 198
页数:5
相关论文
共 50 条
  • [31] Optimisation of treatment of Parkinson's disease with levodopa
    Bialecka, Monika
    Adamiak, Urszulo
    Gawronska-Szklarz, Barbara
    NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2009, 43 (05) : 446 - 459
  • [32] Is levodopa the best treatment for Parkinson's disease?
    Tolosa, E
    EUROPEAN JOURNAL OF NEUROLOGY, 1996, 3 : 5 - 7
  • [33] Levodopa and cognitive disorders in Parkinson's disease
    Leiva-Santana, C.
    Alvarez-Sauco, M.
    REVISTA DE NEUROLOGIA, 2006, 43 (02) : 95 - 100
  • [34] Dysphagia in Parkinson's disease is responsive to levodopa
    Sutton, James P.
    PARKINSONISM & RELATED DISORDERS, 2013, 19 (03) : 282 - 284
  • [35] Levodopa Response in Early Parkinson's Disease
    Hauser, Robert A.
    Auinger, Peggy
    Oakes, David
    MOVEMENT DISORDERS, 2009, 24 (16) : 2328 - 2336
  • [36] The effect of intensive speech rate and intonation therapy on intelligibility in Parkinson's disease
    Martens, Heidi
    Van Nuffelen, Gwen
    Dekens, Tomas
    Huici, Maria Hernandez-Diaz
    Hernandez-Diaz, Hector Arturo Kairuz
    De Letter, Miet
    De Bodt, Marc
    JOURNAL OF COMMUNICATION DISORDERS, 2015, 58 : 91 - 105
  • [37] Levodopa-induced alterations in speech rate in advanced Parkinson's disease
    De Letter, M
    Santens, P
    De Bodt, M
    Boon, P
    Van Borsel, J
    ACTA NEUROLOGICA BELGICA, 2006, 106 (01) : 19 - 22
  • [38] Subthalamic nucleus stimulation and spontaneous language production in Parkinson's disease: A double laterality problem
    Batens, Katja
    De Letter, Miet
    Raedt, Robrecht
    Duyck, Wouter
    Vanhoutte, Sarah
    Van Roost, Dirk
    Santens, Patrick
    BRAIN AND LANGUAGE, 2015, 147 : 76 - 84
  • [39] Effect of onset age on the levodopa threshold dosage for dyskinesia in Parkinson's disease
    Zhang, Zhijin
    Liu, Genliang
    Wang, Dongxu
    Chen, Huimin
    Su, Dongning
    Kou, Wenyi
    Zhao, Jiajia
    Wang, Xuemei
    Wang, Zhan
    Ma, Huizi
    Feng, Tao
    NEUROLOGICAL SCIENCES, 2022, 43 (05) : 3165 - 3174
  • [40] Effect of onset age on the levodopa threshold dosage for dyskinesia in Parkinson's disease
    Zhijin Zhang
    Genliang Liu
    Dongxu Wang
    Huimin Chen
    Dongning Su
    Wenyi Kou
    Jiajia Zhao
    Xuemei Wang
    Zhan Wang
    Huizi Ma
    Tao Feng
    Neurological Sciences, 2022, 43 : 3165 - 3174