Dimethylsilicon(IV) derivatives of amino acids

被引：3

作者：

Nath, M ^{[1
]}

Goyal, S ^{[1
]}

机构：

[1] Univ Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2002年 / 177卷 / 04期

关键词：

amino acids; antimicrobial activity; dichlorodimethylsilicon(IV); complexes; multinuclear NMR;

D O I：

10.1080/10426500210662

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reactions of dichlorodimethylsilane with the sodium salt of amino acids in 1:2 molar ratio led to the formation of a new series of dimethylsilicon(IV) complexes of general formula, Me2SiL2 [L = anion of amino acids, viz. glycine (HGly), L-methionine (L-MethH), DL-alpha-alanine (DL-alpha-AlaH) L-leucine (L-LeUH), L-valine (L-ValH) and D-phenylalanine (D-PheH)]. The complexes have been characterized by elemental analyses, molar conductance, and electronic spectra, and the bonding in these complexes is discussed in terms of their infrared, H-1 and C-13 NMR spectra. A distorted octahedral structure with trans methyl groups has been tentatively suggested for the complexes. The complexes, found soluble in DMSO, have been tested in vitro against various bacteria, viz. Escherichia coli, Pseudomonas putida-2252, Aeromonas formicans, Staphylococcus aureus-740, and fungi, viz. Aspergillus niger ORS-4, Aureobasidium pullulans-1991, Verticillium dahliae-2063, and Penicillium notatum-1348.

引用

页码：841 / 851

页数：11

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