Palladium-Catalyzed Intermolecular Polarity-Mismatched Addition of Unactivated Alkyl Radicals to Unactivated Alkenes

被引：37

作者：

Wu, Xiaojin ^{[1
]}

Xiao, Guanlin ^{[1
,2
]}

Ding, Yalan ^{[1
]}

Zhan, Ying ^{[1
]}

Zhao, Yao ^{[1
]}

Chen, Rizhi ^{[3
]}

Loh, Teck-Peng ^{[4
]}

机构：

[1] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

[2] Guangdong Prov Engn Technol Res Inst Tradit Chine, Guangzhou 510095, Peoples R China

[3] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China

[4] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637616, Singapore

来源：

ACS CATALYSIS | 2020年 / 10卷 / 23期

基金：

中国国家自然科学基金;

关键词：

polarity-mismatched radical addition; unactivated alkenes; heteropolycycles; inert C(sp(3))-C(sp(3)) bond formation; reverse cascade addition process; HECK-TYPE REACTION; C-H ALKYLATIONS; INDOLE-DERIVATIVES; FUNCTIONALIZATION; SECONDARY; HALIDES; OLEFINS; DICARBOFUNCTIONALIZATION; ALKYLARYLATION; ROUTE;

D O I：

10.1021/acscatal.0c04013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A palladium-catalyzed intermolecular polarity-mismatched addition of unactivated alkyl radicals to unactivated alkenes was developed for the first time. In the two-component dicarbofunctionalization, a variety of primary, secondary, and tertiary unactivated alkyl halides regioselectively reacted with various unactivated olefins. A series of structurally complex heteropolycycles decorated with a quaternary carbon center have been efficiently synthesized.

引用

页码：14107 / 14116

页数：10

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