Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity

被引：12

作者：

Kullman, SW ^{[1
]}

Kashiwada, S ^{[1
]}

Hinton, DE ^{[1
]}

机构：

[1] Duke Univ, Nicholas Sch Environm & Earth SCi, Durham, NC 27708 USA

来源：

MARINE ENVIRONMENTAL RESEARCH | 2004年 / 58卷 / 2-5期

关键词：

D O I：

10.1016/j.marenvres.2004.03.030

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We have previously demonstrated that medaka CYP3A is associated with metabolism of several endobiotics including steroids and bile acids. In this study, we demonstrate that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models. Using 7-benzyloxy-4-(trifluoromethyl)-coumarin (BFC) and nonylphenol as CYP3A substrates, we describe both homotropic and heterotropic cooperative interactions. Given the role of CYP3A in maintaining the homeostatic balance for numerous endobiotics, enzymatic activation/inhibition by endocrine disruptors (EDCs) represents a putative (non-genomic) mechanism for endocrine disruption. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：469 / 473

页数：5

共 50 条

[41] Factors Affecting the Clinical Development of Cytochrome P450 3A Substrates [J].

Megan A. Gibbs ;

Natilie A. Hosea .

Clinical Pharmacokinetics, 2003, 42 :969-984

[42] In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids [J].

Basheer, Loai ;

Schultz, Keren ;

Guttman, Yelena ;

Kerem, Zohar .

FOOD CHEMISTRY, 2017, 237 :895-903

[43] Cytochrome P450 3A expression and activity in the human small intestine [J].

Yang, JS ;

Tucker, GT ;

Rostami-Hodjegan, A .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2004, 76 (04) :391-391

[44] Induction of cytochrome P450 3A by retinoids in rat hepatocyte culture [J].

JurimaRomet, M ;

Neigh, S ;

Casley, WL .

HUMAN & EXPERIMENTAL TOXICOLOGY, 1997, 16 (04) :198-203

[45] Suppression of cytochrome P450 3A protein levels by proteasome inhibitors [J].

Zangar, RC ;

Kocarek, TA ;

Shen, S ;

Bollinger, N ;

Dahn, MS ;

Lee, DW .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 305 (03) :872-879

[46] Effect of Intestinal Cytochrome P450 3A on Phytochemical Presystemic Metabolism [J].

夏芳 ;

陈孝银 .

Chinese Journal of Integrated Traditional and Western Medicine, 2005, (03) :232-236

[47] A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes [J].

Gushchin, GV ;

Gushchin, MI ;

Gerber, N ;

Boyd, RT .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 255 (02) :394-398

[48] Screening for cytochrome P450 3A in man: Studies with midazolam and nifedipine [J].

Yeates, RA ;

Scharpf, F ;

Laufen, H ;

Zimmermann, T .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1996, 48 (09) :933-934

[49] Effects of Intestinal Flora on the Expression of Cytochrome P450 3A in the Liver [J].

Ishii, Makoto ;

Toda, Takahiro ;

Ikarashi, Nobutomo ;

Ochiai, Wataru ;

Sugiyama, Kiyoshi .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2012, 132 (03) :301-310

[50] Comparison of Cytochrome P450 3A Enzymes in Cynomolgus Monkeys and Humans [J].

Iwasaki, Kazuhide ;

Murayama, Norie ;

Koizumi, Ryo ;

Uno, Yasuhiro ;

Yamazaki, Hiroshi .

DRUG METABOLISM AND PHARMACOKINETICS, 2010, 25 (04) :388-391

← 1 2 3 4 5 →