An efficient approach to chloro(organophosphine) gold(I) complexes for the synthesis of auranofin

被引：10
|
作者：
Wang, Junchang [1 ]
Mi, Xuemeng [1 ]
Wang, Jiazhe [1 ]
Yang, You [1 ]
机构：
[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China
来源：
GREEN CHEMISTRY | 2017年 / 19卷 / 03期
关键词：
GLYCOSYL ORTHO-ALKYNYLBENZOATES; N-HETEROCYCLIC CARBENE; PROPARGYL 1,2-ORTHOESTERS; STEREOSELECTIVE-SYNTHESIS; PHOSPHINE COMPLEXES; ANTITUMOR-ACTIVITY; ANTICANCER; CATALYSIS; DONORS; DRUGS;
D O I：
10.1039/c6gc02908f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A practical and efficient synthesis of chloro(organophosphine) gold(I) complexes is reported. Employment of 4,4'-dihydroxydiphenyl sulfide as a safe and non-irritating reductant is highlighted for the generation of Au(I)-S intermediates, which could be trapped by mono-and bidentate phosphine ligands to provide organophosphine gold(I) complexes. The utility of the present method is further demonstrated by the synthesis of the antiarthritic drug auranofin.
引用
收藏
页码：634 / 637
页数：4
相关论文
共 50 条
  • [21] The photochemistry of chloro(triphenylphosphine)gold(I) and trichloro(triphenylphosphine)gold(III) in chloroform
    Serafimova, IM
    Hoggard, PE
    INORGANICA CHIMICA ACTA, 2002, 338 : 105 - 110
  • [22] Silver(I) and gold(I) complexes of diethylmalonate
    Skriba, Anton
    Jasikova, Lucie
    Roithova, Jana
    INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2012, 330 : 226 - 232
  • [23] A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin
    De Luca, Anastasia
    Hartinger, Christian G.
    Dyson, Paul J.
    Lo Bello, Mario
    Casini, Angela
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2013, 119 : 38 - 42
  • [24] Synthesis and anticancer properties of gold(I) and silver(I) N-heterocyclic carbene complexes
    Siciliano, Tammy J.
    Deblock, Michael C.
    Hindi, Khadijah M.
    Durmus, Semih
    Panzner, Matthew J.
    Tessier, Claire A.
    Youngs, Wiley J.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2011, 696 (05) : 1066 - 1071
  • [25] Efficient Computation of Geometries for Gold Complexes
    Leach, Isaac F.
    Belpassi, Leonardo
    Belanzoni, Paola
    Havenith, Remco W. A.
    Klein, Johannes E. M. N.
    CHEMPHYSCHEM, 2021, 22 (12) : 1262 - 1268
  • [26] Cationic NHC-gold(I) complexes: Synthesis, isolation, and catalytic activity
    de Fremont, Pierre
    Marion, Nicolas
    Nolan, Steven P.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2009, 694 (04) : 551 - 560
  • [27] Gold(I)-Catalyzed Asymmetric Synthesis of Planar Chiral Arene Chromium Complexes
    Murai, Masato
    Uenishi, Jun'ichi
    Uemura, Motokazu
    ORGANIC LETTERS, 2010, 12 (21) : 4788 - 4791
  • [28] Synthesis and structural studies of some gold(I) complexes containing selenoureato ligands
    Molter, Anja
    Rust, Joerg
    Lehmann, Christian W.
    Mohr, Fabian
    TETRAHEDRON, 2012, 68 (51) : 10586 - 10591
  • [29] Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases
    Lu, Yunlong
    Ma, Xiaoyan
    Chang, Xingyu
    Liang, Zhenlin
    Lv, Lin
    Shan, Min
    Lu, Qiuyue
    Wen, Zhenfan
    Gust, Ronald
    Liu, Wukun
    CHEMICAL SOCIETY REVIEWS, 2022, 51 (13) : 5518 - 5556
  • [30] Synthesis, anticancer activity and apoptosis induction of gold(I) complexes containing tris(o-methoxyphenyl)phosphane
    Sulaiman, Adam A. A.
    Alhoshani, Ali
    Ahmad, Saeed
    Peedikakkal, Abdul Malik Puthan
    Abogosh, Ahmed K.
    Alghanem, Meshal
    Mahmoud, Mohamed A.
    Alanazi, W. A.
    Alasmael, Noura
    Monim-ul-Mehboob, Muhammad
    Isab, Anvarhusein A.
    INORGANICA CHIMICA ACTA, 2021, 527
12345