Mass Spectrometric Detection of Nanoparticle Host-Guest Interactions in Cells

被引：16

作者：

Yan, Bo ^{[1
]}

Tonga, Gulen Yesilbag ^{[1
]}

Hou, Singyuk ^{[1
]}

Fedick, Patrick W. ^{[1
]}

Yeh, Yi-Cheun ^{[1
]}

Alfonso, Felix S. ^{[1
]}

Mizuhara, Tsukasa ^{[1
]}

Vachet, Richard W. ^{[1
]}

Rotello, Vincent M. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

ANALYTICAL CHEMISTRY | 2014年 / 86卷 / 13期

关键词：

SELF-ASSEMBLED MONOLAYERS; PROTECTED GOLD NANOPARTICLES; SILICA NANOPARTICLES; HYDROPHOBIC DRUGS; LIVE CELLS; GAS-PHASE; CHEMISTRY; RECOGNITION; BINDING; DELIVERY;

D O I：

10.1021/ac501682y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Synthetic host-guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host-guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describe and apply a mass spectrometric method to monitor the association and dissociation of nanoparticle (NP)-based host-guest interactions that integrates NP-assisted laser desorption/ionization (LDI) and matrix assisted laser desoption/ionization (MALDI) mass spectrometry. This LDI/MALDI approach reveals how NP surface functionality affects host-guest interactions in cells, information difficult to achieve using other techniques.

引用

收藏

页码：6710 / 6714

页数：5

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