DH1R132, DH2R140 and 1DH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies

被引：34

作者：

Meggendorfer, Manja ^{[1
]}

Cappelli, Luca Vincenzo ^{[2
]}

Walter, Wencke ^{[1
]}

Haferlach, Claudia ^{[1
]}

Kern, Wolfgang ^{[1
]}

Falini, Brunangelo ^{[3
,4
,5
]}

Haferlach, Torsten ^{[1
]}

机构：

[1] MLL Munich Leukemia Lab, Munich, Germany

[2] Sapienza Univ, Dept Cellular Biotechnol & Hematol, Rome, Italy

[3] Univ Perugia, Inst Hematol, Perugia, Italy

[4] Hosp Perugia, Perugia, Italy

[5] Univ Perugia, Ctr Hematooncol Res, Perugia, Italy

来源：

LEUKEMIA | 2018年 / 32卷 / 05期

关键词：

ACUTE MYELOID-LEUKEMIA; CLASSIFICATION; MUTATIONS;

D O I：

10.1038/s41375-018-0026-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：1250 / +

页数：5

共 10 条

[1] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[2] PROPOSALS FOR CLASSIFICATION OF ACUTE LEUKEMIAS [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1976, 33 (04) :451-&

[3] Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence [J].

Genovese, Giulio ;

Kaehler, Anna K. ;

Handsaker, Robert E. ;

Lindberg, Johan ;

Rose, Samuel A. ;

Bakhoum, Samuel F. ;

Chambert, Kimberly ;

Mick, Eran ;

Neale, Benjamin M. ;

Fromer, Menachem ;

Purcell, Shaun M. ;

Svantesson, Oscar ;

Landen, Mikael ;

Hoeglund, Martin ;

Lehmann, Soeren ;

Gabriel, Stacey B. ;

Moran, Jennifer L. ;

Lander, Eric S. ;

Sullivan, Patrick F. ;

Sklar, Pamela ;

Groenberg, Henrik ;

Hultman, Christina M. ;

McCarroll, Steven A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (26) :2477-2487

[4] Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials [J].

Grimwade, David ;

Hills, Robert K. ;

Moorman, Anthony V. ;

Walker, Helen ;

Chatters, Stephen ;

Goldstone, Anthony H. ;

Wheatley, Keith ;

Harrison, Christine J. ;

Burnett, Alan K. .

BLOOD, 2010, 116 (03) :354-365

[5] Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas [J].

Leather, Thomas ;

Jenkinson, Michael D. ;

Das, Kumar ;

Poptani, Harish .

METABOLITES, 2017, 7 (02)

[6] Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia [J].

Ley, Timothy J. ;

Miller, Christopher ;

Ding, Li ;

Raphael, Benjamin J. ;

Mungall, Andrew J. ;

Robertson, A. Gordon ;

Hoadley, Katherine ;

Triche, Timothy J., Jr. ;

Laird, Peter W. ;

Baty, Jack D. ;

Fulton, Lucinda L. ;

Fulton, Robert ;

Heath, Sharon E. ;

Kalicki-Veizer, Joelle ;

Kandoth, Cyriac ;

Klco, Jeffery M. ;

Koboldt, Daniel C. ;

Kanchi, Krishna-Latha ;

Kulkarni, Shashikant ;

Lamprecht, Tamara L. ;

Larson, David E. ;

Lin, Ling ;

Lu, Charles ;

McLellan, Michael D. ;

McMichael, Joshua F. ;

Payton, Jacqueline ;

Schmidt, Heather ;

Spencer, David H. ;

Tomasson, Michael H. ;

Wallis, John W. ;

Wartman, Lukas D. ;

Watson, Mark A. ;

Welch, John ;

Wendl, Michael C. ;

Ally, Adrian ;

Balasundaram, Miruna ;

Birol, Inanc ;

Butterfield, Yaron ;

Chiu, Readman ;

Chu, Andy ;

Chuah, Eric ;

Chun, Hye-Jung ;

Corbett, Richard ;

Dhalla, Noreen ;

Guin, Ranabir ;

He, An ;

Hirst, Carrie ;

Hirst, Martin ;

Holt, Robert A. ;

Jones, Steven .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (22) :2059-2074

[7] Acute myeloid leukemia ontogeny is defined by distinct somatic mutations [J].

Lindsley, R. Coleman ;

Mar, Brenton G. ;

Mazzola, Emanuele ;

Grauman, Peter V. ;

Shareef, Sarah ;

Allen, Steven L. ;

Pigneux, Arnaud ;

Wetzler, Meir ;

Stuart, Robert K. ;

Erba, Harry P. ;

Damon, Lloyd E. ;

Powel, Bayard L. ;

Lindeman, Neal ;

Steensma, David P. ;

Wadleigh, Martha ;

DeAngelo, Daniel J. ;

Neuberg, Donna ;

Stone, Richard M. ;

Ebert, Benjamin L. .

BLOOD, 2015, 125 (09) :1367-1376

[8] Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia [J].

Metzeler, Klaus H. ;

Herold, Tobias ;

Rothenberg-Thurley, Maja ;

Amler, Susanne ;

Sauerland, Maria C. ;

Gorlich, Dennis ;

Schneider, Stephanie ;

Konstandin, Nikola P. ;

Dufour, Annika ;

Braundl, Kathrin ;

Ksienzyk, Bianka ;

Zellmeier, Evelyn ;

Hartmann, Luise ;

Greif, Philipp A. ;

Fiegl, Michael ;

Subklewe, Marion ;

Bohlander, Stefan K. ;

Krug, Utz ;

Faldum, Andreas ;

Berdel, Wolfgang E. ;

Wormann, Bernhard ;

Buchner, Thomas ;

Hiddemann, Wolfgang ;

Braess, Jan ;

Spiekermann, Karsten .

BLOOD, 2016, 128 (05) :686-698

[9] Genomic Classification and Prognosis in Acute Myeloid Leukemia [J].

Papaemmanuil, Elli ;

Gerstung, Moritz ;

Bullinger, Lars ;

Gaidzik, Verena I. ;

Paschka, Peter ;

Roberts, Nicola D. ;

Potter, Nicola E. ;

Heuser, Michael ;

Thol, Felicitas ;

Bolli, Niccolo ;

Gundem, Gunes ;

Van Loo, Peter ;

Martincorena, Inigo ;

Ganly, Peter ;

Mudie, Laura ;

McLaren, Stuart ;

O'Meara, Sarah ;

Raine, Keiran ;

Jones, David R. ;

Teague, Jon W. ;

Butler, Adam P. ;

Greaves, Mel F. ;

Ganser, Arnold ;

Doehner, Konstanze ;

Schlenk, Richard F. ;

Doehner, Hartmut ;

Campbell, Peter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (23) :2209-2221

[10] Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases [J].

Xu, Wei ;

Yang, Hui ;

Liu, Ying ;

Yang, Ying ;

Wang, Ping ;

Kim, Se-Hee ;

Ito, Shinsuke ;

Yang, Chen ;

Wang, Pu ;

Xiao, Meng-Tao ;

Liu, Li-xia ;

Jiang, Wen-qing ;

Liu, Jing ;

Zhang, Jin-ye ;

Wang, Bin ;

Frye, Stephen ;

Zhang, Yi ;

Xu, Yan-hui ;

Lei, Qun-ying ;

Guan, Kun-Liang ;

Zhao, Shi-min ;

Xiong, Yue .

CANCER CELL, 2011, 19 (01) :17-30

← 1 →