Effects of kappa opioid receptors on conditioned place aversion and social interaction in males and females

被引:43
作者
Robles, Cindee F. [1 ,2 ]
McMackin, Marissa Z. [3 ]
Campi, Katharine L. [1 ,4 ]
Doig, Ian E. [1 ]
Takahashi, Elizabeth Y. [1 ]
Pride, Michael C. [1 ]
Trainor, Brian C. [1 ,3 ,4 ]
机构
[1] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA
[2] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA
[3] Univ Calif Davis, Mol Cellular & Integrat Physiol Grad Grp, Davis, CA 95616 USA
[4] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA
关键词
Kappa opioid receptor; Aversion; Sex Difference; Social behavior; INDUCED BEHAVIORAL-RESPONSES; NUCLEUS-ACCUMBENS SHELL; DOPAMINE D1 RECEPTORS; SEX-DIFFERENCES; DEER MICE; PREFERENCE PARADIGM; AGONIST SALVINORIN; LOCOMOTOR-ACTIVITY; INDUCED ANALGESIA; COCAINE REWARD;
D O I
10.1016/j.bbr.2014.01.003
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of kappa opioid receptors (KOR) on motivated behavior are well established based on studies in male rodents, but relatively little is known about the effects of KOR in females. We examined the effects of KOR activation on conditioned place aversion and social interaction in the California mouse (Peromyscus californicus). Important differences were observed in long-term (place aversion) and short-term (social interaction) effects. Females but not males treated with a 2.5 mg/kg dose of U50,488 formed a place aversion, whereas males but not females formed a place aversion at the 10 mg/kg dose. In contrast the short term effects of different doses of U50,488 on social interaction behavior were similar in males and females. Acute injection with 10 mg/kg of U50,488 (but not lower doses) reduced social interaction behavior in both males and females. The effects of U50,488 on phosphorylated extracellular signal regulated kinase (pERK) and p38 MAP kinase were cell type and region specific. Higher doses of U50,488 increased the number of pERK neurons in the ventrolateral bed nucleus of the stria terminals in males but not females, a nucleus implicated in male aggressive behavior. In contrast, both males and females treated with U50,488 had more activated p38 cells in the nucleus accumbens shell. Unexpectedly, cells expressing activated p38 co-expressed Iba-1, a widely used microglia marker. In summary we found strong sex differences in the effects of U50,488 on place aversion whereas the acute effects on U50,488 induced similar behavioral effects in males and females. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:84 / 93
页数:10
相关论文
共 50 条
[31]   Effects of defeat stress on behavioral flexibility in males and females: modulation by the mu-opioid receptor [J].
Laredo, Sarah A. ;
Steinman, Michael Q. ;
Robles, Cindee F. ;
Ferrer, Emilio ;
Ragen, Benjamin J. ;
Trainor, Brian C. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2015, 41 (04) :434-441
[32]   Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats [J].
Anderson, Rachel I. ;
Morales, Melissa ;
Spear, Linda P. ;
Varlinskaya, Elena I. .
PSYCHOPHARMACOLOGY, 2014, 231 (08) :1687-1693
[33]   Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration [J].
Robin E. Sperling ;
Stacey M. Gomes ;
Elizabeth I. Sypek ;
Amanda N. Carey ;
Jay P. McLaughlin .
Psychopharmacology, 2010, 210 :199-209
[34]   Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration [J].
Sperling, Robin E. ;
Gomes, Stacey M. ;
Sypek, Elizabeth I. ;
Carey, Amanda N. ;
McLaughlin, Jay P. .
PSYCHOPHARMACOLOGY, 2010, 210 (02) :199-209
[35]   Molecular and cellular mechanisms for differential effects of chronic social isolation stress in males and females [J].
Wang, Zi-Jun ;
Shwani, Treefa ;
Liu, Junting ;
Zhong, Ping ;
Yang, Fengwei ;
Schatz, Kelcie ;
Zhang, Freddy ;
Pralle, Arnd ;
Yan, Zhen .
MOLECULAR PSYCHIATRY, 2022, 27 (07) :3056-3068
[36]   Oxycodone Conditioned Place Preference Redistributes Delta Opioid Receptors Within Rat Hippocampal Neurons in a Sex-Dependent Manner [J].
Milner, Teresa ;
Contoreggi, Natalina ;
Bshesh, Farah ;
Zhou, Yan ;
Ben, Konrad ;
Gray, Jason ;
Kogan, Josh ;
McEwen, Bruce ;
Kreek, Mary Jeanne .
NEUROPSYCHOPHARMACOLOGY, 2017, 42 :S649-S649
[37]   The effects of the naltrexone implant on rodent social interactions and cocaine-induced conditioned place preference [J].
Mitchem, LD ;
Kruschel, CK ;
Dallman, E ;
Anders, KA ;
Czapiga, M ;
Panos, JJ ;
Steinpreis, RE .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1999, 62 (01) :97-102
[38]   Differential effects of the MEK inhibitor SL327 on the acquisition and expression of ethanol-elicited conditioned place preference and aversion in mice [J].
Rosas, Michela ;
Porru, Simona ;
Longoni, Rosanna ;
Spina, Liliana ;
Peana, Alessandra T. ;
Collu, Maria ;
Acquas, Elio .
JOURNAL OF PSYCHOPHARMACOLOGY, 2017, 31 (01) :105-114
[39]   Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females [J].
Steinman, M. Q. ;
Laredo, S. A. ;
Lopez, E. M. ;
Manning, C. E. ;
Hao, R. C. ;
Doig, I. E. ;
Campi, K. L. ;
Flowers, A. E. ;
Knight, J. K. ;
Trainor, B. C. .
PSYCHONEUROENDOCRINOLOGY, 2015, 51 :122-134
[40]   Long-term effects of repeated social stress on the conditioned place preference induced by MDMA in mice [J].
Garcia-Pardo, M. P. ;
Blanco-Gandia, M. C. ;
Valiente-Lluch, M. ;
Rodriguez-Arias, M. ;
Minarro, J. ;
Aguilar, M. A. .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2015, 63 :98-109