Sphinxolides E-G and reidispongiolide C:: Four new cytotoxic macrolides from the New Caledonian Lithistida sponges N-superstes and R-coerulea

被引：23

作者：

Carbonelli, S

Zampella, A

Randazzo, A

Debitus, C

Gomez-Paloma, L

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Salerno, Dipartimento Sci Farmaceut, DIFARMA, I-84084 Fisciano, SA, Italy

[3] Ctr Noumea, IRD ORSTOM, Noumea, New Caledonia

来源：

TETRAHEDRON | 1999年 / 55卷 / 51期

关键词：

marine sponge; Neosiphonia superstes; Reidispongia coerulea; macrolides; cytotoxic; 2D-NMR;

D O I：

10.1016/S0040-4020(99)00912-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new macrolides (7-10), structurally related to known sphinxolides (1-4) and reidispongiolides (5-6), have been isolated following a reinvestigation of Neosiphonia superstes and Reidispongia coerulea, two Lithistida sponges collected in the deep waters off New Caledonia. In this paper we report their structure elucidation based on spectral data (mainly 2D-NMR and MS) as well as their cytotoxicity determined on a panel of 60 human cancer cell lines (NCI in vitro primary screen). (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：14665 / 14674

页数：10

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