DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells

被引：24
|
作者：
Yu, Wei [1 ]
Xu, Ying-Chen [2 ]
Tao, Ying [1 ]
He, Ping [2 ]
Li, Yang [2 ]
Wu, Tao [1 ]
Zhu, Yan-Pei [1 ]
Li, Jing [3 ]
Wu, Ji-Xiang [4 ]
Dai, Jie [1 ]
机构：
[1] Capital Med Univ, Ctr Clin Pathol, Beijing 100069, Peoples R China
[2] Capital Med Univ, Beijing Anzhen Hosp, Dept Gen Surg, Beijing 100029, Peoples R China
[3] Beijing Aerosp Gen Hosp, Dept Pathol, Beijing 100076, Peoples R China
[4] Capital Med Univ, Beijing Tongren Hosp, Beijing 100730, Peoples R China
来源：
ONCOLOGY REPORTS | 2013年 / 30卷 / 06期
基金：
中国国家自然科学基金;
关键词：
DcR3; colon cancer; RNAi; MMPs; VEGFs; DECOY RECEPTOR-3; CLINICAL-SIGNIFICANCE; ESOPHAGEAL-CARCINOMA; VEGF-D; PROLIFERATION; SUPERFAMILY; INHIBITION; EXPRESSION; MIGRATION; SURVIVAL;
D O I：
10.3892/or.2013.2769
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Decoy receptor 3 (DcR3) is considered to have anti-apoptotic and pro-metastatic functions, suggesting it might be a therapeutic target. We examined the role and mechanisms of DcR3 on growth and the metastatic ability of SW480 colon cancer cells to provide therapeutic information for targeting DcR3 by RNA interference (RNAi) technology. Growth and the metastatic ability were inhibited, apoptosis was induced and cell cycle profile was changed after decreasing DcR3 expression, with lower levels of vascular endothelial growth factors (VEGFs) and matrix metalloproteinases (MMPs) expression. Our results implied the therapeutic potential of silencing DcR3 expression by RNAi in colon cancer.
引用
收藏
页码：2741 / 2748
页数：8
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