General anaesthetic action at transmitter-gated inhibitory amino acid receptors

被引：121
作者：
Belelli, D
Pistis, M
Peters, JA
Lambert, JJ
机构：
[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Pharmacol & Neurosci, Dundee DD1 9SY, Scotland
[2] Dipartimento Neurosci, Cagliari, Italy
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1999年 / 20卷 / 12期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0165-6147(99)01405-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Research within the past decade has provided compelling evidence that anaesthetics can act directly as allosteric modulators of transmitter-gated ion channels. Recent comparative studies of the effects of general anaesthetics across a structurally homologous family of inhibitory amino acid receptors that includes mammalian GABA(A), glycine and Drosophila RDL GABA receptors have provided new insights into the structural basis of anaesthetic action at transmitter-gated channels. In this article, the differential effects of general anaesthetics across inhibitory amino acid receptors and the potential relevance of such actions to general anaesthesia will be discussed.
引用
收藏
页码：496 / 502
页数：7
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