Updates on Histiocytic Disorders

被引：82

作者：

Vaiselbuh, Sarah R. ^{[1
]}

Bryceson, Yenan T. ^{[2
]}

Allen, Carl E. ^{[3
]}

Whitlock, James A. ^{[4
,5
]}

Abla, Oussama ^{[4
]}

机构：

[1] Staten Isl Univ Hosp, Childrens Canc Ctr, Staten Isl, NY 10305 USA

[2] Karolinska Inst, Ctr Infect Med, Stockholm, Sweden

[3] Baylor Coll Med, Dept Pediat, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[4] Hosp Sick Children, Garron Family Canc Ctr, Toronto, ON M5G 1X8, Canada

[5] Hosp Sick Children, Dept Hematol Oncol, Toronto, ON M5G 1X8, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2014年 / 61卷 / 07期

关键词：

allogeneic BMT; voriconazole; phototoxicity; ROSAI-DORFMAN-DISEASE; LANGERHANS-CELL HISTIOCYTOSIS; FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; ERDHEIM-CHESTER DISEASE; SINUS HISTIOCYTOSIS; MASSIVE LYMPHADENOPATHY; DENDRITIC CELLS; SALVAGE THERAPY; MUTATIONS; VEMURAFENIB;

D O I：

10.1002/pbc.25017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the incidence of phototoxic skin reactions in pediatric BMT recipients treated with voriconazole. Nine out of 40 patients (22.5%), all Caucasian, developed skin lesions in sun-exposed distributions. Dermatologic findings included sunburn-like erythema, pseudo-porphyria, linear papulovesicular lesions, severe erosive cheilitis, dermatoheliosis and lentigines. Patients were treated with sun avoidance, high-potency sunscreens, and topical steroids with significant improvement in all cases. Prolonged voriconazole use requires close monitoring for chronic skin toxicities. Long-term risks including the risk of skin cancer need to be investigated. Pediatr Blood Cancer 2014;61:1325-1328. (c) 2014 Wiley Periodicals, Inc.

引用

页码：1329 / 1335

页数：7

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