Two new alkaloid metabolites produced by endophytic fungus Stagonosporopsis oculihominis isolated from Dendrobium huoshanense

被引：16
|
作者：
Yu, Yang [1 ]
Ma, Bing-ji [2 ]
Liu, Jin-song [1 ]
Yue, Jing-yi [1 ]
Chen, He-ping [3 ]
Liang, Yi-min [1 ]
Zhou, Zhong-yu [4 ]
Wang, Guo-kai [1 ]
Wang, Gang [1 ]
机构：
[1] Anhui Univ Chinese Med, Sch Pharm, Anhui Key Lab Modern Chinese Mat Med, Hefei 230031, Peoples R China
[2] Henan Agr Univ, Dept Tradit Chinese Med, Zhengzhou 450002, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Kunming 650201, Peoples R China
[4] Chinese Acad Sci, Guang Dong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2017年 / 19卷
关键词：
Alkaloid; Endophytic fungus; Stagonosporopsis oculihominis; Cytotoxicity; TETRACYCLIC TRITERPENOIDS; FUSARIUM SP; BACTERIUM;
D O I：
10.1016/j.phytol.2017.02.006
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new alkaloids (1-2), together with six known compounds (3-8), were isolated from cultures of the endophytic fungus Stagonosporopsis oculihominis. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and HRMS analyses. The absolute configurations of 1 was determined by the comparison of experimental and theoretical electronic circular dichroism spectra. The new compounds were investigated for their cytotoxicity against five human cancer cell lines. (C) 2017 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：266 / 270
页数：5
相关论文
共 50 条
  • [1] (±)-Stagonosporopsin A, stagonosporopsin B and stagonosporopsin C, antibacterial metabolites produced by endophytic fungus Stagonosporopsis oculihominis
    Wang, Ju-Tao
    Li, Hui-Yuan
    Rao, Rao
    Yue, Jing-Yi
    Wang, Guo-Kai
    Yu, Yang
    PHYTOCHEMISTRY LETTERS, 2021, 45 : 157 - 160
  • [2] Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium officinale
    Wu, Ling-Shang
    Jia, Min
    Chen, Ling
    Zhu, Bo
    Dong, Hong-Xiu
    Si, Jin-Ping
    Peng, Wei
    Han, Ting
    MOLECULES, 2016, 21 (01):
  • [3] Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba
    Qin, Jian-Chun
    Zhang, Ya-Mei
    Gao, Jin-Ming
    Bai, Ming-Sheng
    Yang, Sheng-Xiang
    Laatsch, Hartmut
    Zhang, An-Ling
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (06) : 1572 - 1574
  • [4] AN ANTIMICROBIAL ALKALOID AND OTHER METABOLITES PRODUCED BY Penicillium sp AN ENDOPHYTIC FUNGUS ISOLATED FROM Mauritia flexuosa L. f.
    Ferreira Koolen, Hector Henrique
    Soares, Elzalina Ribeiro
    Araujo da Silva, Felipe Moura
    de Almeida, Richardson Alves
    Leao de Souza, Afonso Duarte
    de Medeiros, Livia Soman
    Rodrigues Filho, Edson
    Lima de Souza, Antonia Queiroz
    QUIMICA NOVA, 2012, 35 (04): : 771 - 774
  • [5] Metabolites Isolated from an Endophytic Fungus of Annulohypoxylon elevatidiscus
    Cheng, Ming-Jen
    Wu, Ming-Der
    Cheng, Yen-Chen
    Chen, Jih-Jung
    Hsieh, Sung-Yuan
    Yuan, Gwo-Fang
    Su, Yung-Shun
    CHEMISTRY OF NATURAL COMPOUNDS, 2015, 51 (01) : 67 - 70
  • [6] Two new metabolites from the endophytic fungus Xylaria sp isolated from the medicinal plant Curcuma xanthorrhiza
    Hammerschmidt, Lena
    Ola, Antonius
    Mueller, Werner E. G.
    Lin, WenHan
    Mandi, Attila
    Kurtan, Tibor
    Proksch, Peter
    Aly, Amal H.
    TETRAHEDRON LETTERS, 2015, 56 (10) : 1193 - 1197
  • [7] Metabolites Isolated from an Endophytic Fungus of Annulohypoxylon elevatidiscus
    Ming-Jen Cheng
    Ming-Der Wu
    Yen-Chen Cheng
    Jih-Jung Chen
    Sung-Yuan Hsieh
    Gwo-Fang Yuan
    Yung-Shun Su
    Chemistry of Natural Compounds, 2015, 51 : 67 - 70
  • [8] Two new metabolites from the mangrove endophytic fungus no. 2106
    Wang, San-Yong
    Xu, Zhong-Liang
    She, Zhi-Gang
    Wang, Hui
    Li, Chun-Rong
    Lin, Yong-Cheng
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, 10 (07) : 622 - 626
  • [9] Two new metabolites from the mangrove endophytic fungus no. 2524
    Li, HJ
    Lin, YC
    Yao, JH
    Vrijmoed, LLP
    Jones, EBG
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2004, 6 (03) : 185 - 191
  • [10] Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica
    Sun, Zhang-Hua
    Li, Hao-Hua
    Liang, Fa-Liang
    Chen, Yu-Chan
    Liu, Hong-Xin
    Li, Sai-Ni
    Tan, Guo-Hui
    Zhang, Wei-Min
    MOLECULES, 2016, 21 (07)
12345