The role of RNA binding proteins in hepatocellular carcinoma

被引：18

作者：

Zhang, Kai ^{[1
,2
]}

Barry, Anna E. ^{[1
,2
]}

Lamm, Ryan ^{[1
]}

Patel, Keyur ^{[1
]}

Schafer, Michelle ^{[1
]}

Dang, Hien ^{[1
,2
]}

机构：

[1] Thomas Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA

[2] Sidney Kimmel Canc Ctr, Philadelphia, PA USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2022年 / 182卷

关键词：

Hepatocellular carcinoma; RNA binding protein; Therapeutic targets; HEPATIC STELLATE-CELLS; C VIRUS-RNA; LONG NONCODING RNAS; FATTY LIVER-DISEASE; LARGE-SCALE ANALYSIS; ALTERNATIVE POLYADENYLATION; GENE-EXPRESSION; MOLECULAR-MECHANISMS; S-ADENOSYLMETHIONINE; SPLICING REGULATION;

D O I：

10.1016/j.addr.2022.114114

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the leading causes of overall cancer deaths worldwide with limited therapeutic options. Due to the heterogeneity of HCC pathogenesis, the molecular mechanisms underlying HCC development are not fully understood. Emerging evidence indicates that RNA-binding proteins (RBPs) play a vital role throughout hepatocarcinogenesis. Thus, a deeper understanding of how RBPs contribute to HCC progression will provide new tools for early diagnosis and prognosis of this devastating disease. In this review, we summarize the tumor suppressive and oncogenic roles of RBPs and their roles in hepatocarcinogenesis. The diagnostic and therapeutic potential of RBPs in HCC, including their limitations, are also discussed. (c) 2022 Elsevier B.V. All rights reserved.

引用

页数：14

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